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Trpm8 transient receptor potential cation channel, subfamily M, member 8 [ Mus musculus (house mouse) ]

Gene ID: 171382, updated on 27-Nov-2024

Summary

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Official Symbol
Trpm8provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 8provided by MGI
Primary source
MGI:MGI:2181435
See related
Ensembl:ENSMUSG00000036251 AllianceGenome:MGI:2181435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CMR1; TRPP8; LTRPC6; Trp-p8; LTrpC-6
Summary
Enables calcium channel activity and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including intracellular calcium ion homeostasis; response to cold; and thermoception. Located in external side of plasma membrane and membrane raft. Is expressed in dorsal root ganglion; inferior vagus ganglion; lumbar dorsal root ganglion; and vagus ganglion. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 2.5), CNS E18 (RPKM 0.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Trpm8 in Genome Data Viewer
Location:
1 D; 1 44.57 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88234457..88318909)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88306735..88388853)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene Holliday junction recognition protein Neighboring gene STARR-seq mESC enhancer starr_01631 Neighboring gene STARR-seq mESC enhancer starr_01632 Neighboring gene secreted phosphoprotein 2 Neighboring gene STARR-seq mESC enhancer starr_01633 Neighboring gene predicted gene 29538 Neighboring gene predicted gene 28888

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis. Denda M, et al. Exp Dermatol, 2010 Sep. PMID 20636355
  2. Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. Robbins A, et al. Invest Ophthalmol Vis Sci, 2012 Oct 9. PMID 22952122, Free PMC Article
  3. Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices. Pezzoli M, et al. Sci Rep, 2014 Oct 31. PMID 25359561, Free PMC Article
  4. N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. Pertusa M, et al. J Biol Chem, 2012 May 25. PMID 22493431, Free PMC Article
  5. Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage. Piña R, et al. J Neurosci, 2019 Oct 9. PMID 31471469, Free PMC Article

See all (202) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation.
    Title: Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation.
  2. TRPM8 affects relative "cooling and heating" of subcellular organelles in microglia in a context-dependent manner.
    Title: TRPM8 affects relative "cooling and heating" of subcellular organelles in microglia in a context-dependent manner.
  3. Separation of Oral Cooling and Warming Requires TRPM8.
    Title: Separation of Oral Cooling and Warming Requires TRPM8.
  4. [Effect of TRPM8 on pain symptom and neuronal proliferation in mice with interstitial cystitis/bladder pain syndrome].
    Title: [Effect of TRPM8 on pain symptom and neuronal proliferation in mice with interstitial cystitis/bladder pain syndrome].
  5. Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea.
    Title: Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea.
  6. Modulation of TRPM8 alters the phagocytic activity of microglia and induces changes in sub-cellular organelle functions.
    Title: Modulation of TRPM8 alters the phagocytic activity of microglia and induces changes in sub-cellular organelle functions.
  7. Characterization of TRPM8-expressing neurons in the adult mouse hypothalamus.
    Title: Characterization of TRPM8-expressing neurons in the adult mouse hypothalamus.
  8. Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice.
    Title: Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice.
  9. Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRalpha3.
    Title: Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.
  10. The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature.
    Title: The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature.
Submit: New GeneRIF Correction See all GeneRIFs (122)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (7)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2849

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ligand-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to temperature stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within thermoception IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within thermoception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane raft IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily M member 8
Names
TRP ion channel TRPM8
long transient receptor potential channel 6
transient receptor potential p8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134252.5 → NP_599013.1  transient receptor potential cation channel subfamily M member 8

    See identical proteins and their annotated locations for NP_599013.1

    Status: VALIDATED

    Source sequence(s)
    AC087780, AC102505, FQ976922
    Consensus CDS
    CCDS48316.1
    UniProtKB/Swiss-Prot
    E9Q165, Q148W9, Q8R4D5
    Conserved Domains (2) summary
    TIGR00870
    Location:657 → 1005
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:116 → 386
    LSDAT_euk; SLOG in TRPM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    88234457..88318909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529226.2 → XP_006529289.1  transient receptor potential cation channel subfamily M member 8 isoform X1

    See identical proteins and their annotated locations for XP_006529289.1

    UniProtKB/Swiss-Prot
    E9Q165, Q148W9, Q8R4D5
    Related
    ENSMUSP00000036991.8, ENSMUST00000040210.14
    Conserved Domains (2) summary
    TIGR00870
    Location:657 → 1005
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:116 → 386
    LSDAT_euk; SLOG in TRPM

  2. XM_017319118.2 → XP_017174607.1  transient receptor potential cation channel subfamily M member 8 isoform X2

    Conserved Domains (1) summary
    cl39032
    Location:116 → 386
    LSDAT_euk; SLOG in TRPM

  3. XM_006529225.2 → XP_006529288.1  transient receptor potential cation channel subfamily M member 8 isoform X1

    See identical proteins and their annotated locations for XP_006529288.1

    UniProtKB/Swiss-Prot
    E9Q165, Q148W9, Q8R4D5
    Related
    ENSMUSP00000131209.3, ENSMUST00000171176.3
    Conserved Domains (2) summary
    TIGR00870
    Location:657 → 1005
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:116 → 386
    LSDAT_euk; SLOG in TRPM

  4. XM_006529229.1 → XP_006529292.1  transient receptor potential cation channel subfamily M member 8 isoform X3

    Conserved Domains (1) summary
    TIGR00870
    Location:148 → 496
    trp; transient-receptor-potential calcium channel protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4D5.3 GenPept UniProtKB/Swiss-Prot:Q8R4D5

Gene LinkOut

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