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Cyp2t1 cytochrome P450, family 2, subfamily t, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171380, updated on 27-Nov-2024

Summary

Official Symbol
Cyp2t1provided by RGD
Official Full Name
cytochrome P450, family 2, subfamily t, polypeptide 1provided by RGD
Primary source
RGD:620086
See related
EnsemblRapid:ENSRNOG00000028891 AllianceGenome:RGD:620086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable arachidonate epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 83.9), Lung (RPKM 77.1) and 9 other tissues See more
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Genomic context

See Cyp2t1 in Genome Data Viewer
Location:
1q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91573923..91579215)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82446321..82451564)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (83965370..83969466)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 1, pseudogene 6 Neighboring gene cytochrome P450, family 2, subfamily f, polypeptide 4 Neighboring gene egl-9 family hypoxia-inducible factor 2 Neighboring gene RAB4B, member RAS oncogene family Neighboring gene MIA SH3 domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arachidonate epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cytochrome P450, family 2, subfamily t, polypeptide 1
Names
cytochrome P450 monooxygenase CYP2T1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134369.2NP_599196.2  cytochrome P450, family 2, subfamily t, polypeptide 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K2P4, E9PSZ7
    Related
    ENSRNOP00000072323.1, ENSRNOT00000079995.3
    Conserved Domains (1) summary
    cl41757
    Location:68492
    cytochrome_P450; cytochrome P450 (CYP) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    91573923..91579215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228558.5XP_006228620.1  cytochrome P450, family 2, subfamily t, polypeptide 1 isoform X1

    UniProtKB/TrEMBL
    E9PSZ7
    Conserved Domains (1) summary
    pfam00067
    Location:24455
    p450; Cytochrome P450