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Slc25a21 solute carrier family 25 member 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171151, updated on 9-Dec-2024

Summary

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Official Symbol
Slc25a21provided by RGD
Official Full Name
solute carrier family 25 member 21provided by RGD
Primary source
RGD:621444
See related
EnsemblRapid:ENSRNOG00000008931 AllianceGenome:RGD:621444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Odc1
Summary
Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 18. Orthologous to human SLC25A21 (solute carrier family 25 member 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 86.8), Kidney (RPKM 34.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a21 in Genome Data Viewer
Location:
6q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (79938480..80437937, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (74203439..74702902, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (77624384..78121339, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15, pseudogene 2 Neighboring gene NK2 homeobox 8 Neighboring gene paired box 9 Neighboring gene ALG11, alpha-1,2-mannosyltransferase, pseudogene 2 Neighboring gene uncharacterized LOC108351240 Neighboring gene uncharacterized LOC134479389 Neighboring gene uncharacterized LOC120103539 Neighboring gene transfer RNA valine (anticodon AAC) 44 Neighboring gene U6 spliceosomal RNA Neighboring gene phosphoribosyl pyrophosphate synthetase 1-like 3 Neighboring gene mirror-image polydactyly 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location. Fiermonte G, et al. J Biol Chem, 2001 Mar 16. PMID 11083877
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105329

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-ketoglutarate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-ketoglutarate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial alpha-ketoglutarate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial alpha-ketoglutarate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial 2-oxodicarboxylate carrier
Names
oxodicarboxylate carrier
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133614.3 → NP_598298.1  mitochondrial 2-oxodicarboxylate carrier

    See identical proteins and their annotated locations for NP_598298.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q99JD3
    UniProtKB/TrEMBL
    A0A140TAF1, A6HBP1
    Related
    ENSRNOP00000084175.1, ENSRNOT00000119506.2
    Conserved Domains (2) summary
    PTZ00168
    Location:11 → 280
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:14 → 104
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    79938480..80437937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111745.2 → XP_038967673.1  mitochondrial 2-oxodicarboxylate carrier isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:14 → 104
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JD3.1 GenPept UniProtKB/Swiss-Prot:Q99JD3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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