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Serpini2 serpin family I member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171149, updated on 27-Nov-2024

Summary

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Official Symbol
Serpini2provided by RGD
Official Full Name
serpin family I member 2provided by RGD
Primary source
RGD:619897
See related
EnsemblRapid:ENSRNOG00000009903 AllianceGenome:RGD:619897
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Orthologous to human SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 150.9) and Liver (RPKM 57.7) See more
Orthologs
human mouse all
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Genomic context

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See Serpini2 in Genome Data Viewer
Location:
2q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (162313325..162342875, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (160014721..160044271, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (173640385..173670790, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 1, pseudogene 7 Neighboring gene zinc finger, B-box domain containing Neighboring gene uncharacterized LOC120100849 Neighboring gene WD repeat domain 49 Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene programmed cell death 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells. Hill RM, et al. Ann N Y Acad Sci, 2002 Oct. PMID 12438159
  2. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, et al. Cytogenet Cell Genet, 2001. PMID 11306811
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration
    Title: Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serpin I2
Names
neuroserpin
serine (or cysteine) peptidase inhibitor, clade I, member 2
serpin peptidase inhibitor, clade I (pancpin), member 2
serpin peptidase inhibitor, clade I, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134409.2 → NP_001127881.1  serpin I2 precursor

    See identical proteins and their annotated locations for NP_001127881.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6J5Q3, G3V7A3
    Related
    ENSRNOP00000013452.4, ENSRNOT00000013452.7
    Conserved Domains (1) summary
    cl00137
    Location:23 → 405
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    162313325..162342875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133612.1: Suppressed sequence

    Description
    NM_133612.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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