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Slc6a5 solute carrier family 6 member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171148, updated on 2-Nov-2024

Summary

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Official Symbol
Slc6a5provided by RGD
Official Full Name
solute carrier family 6 member 5provided by RGD
Primary source
RGD:621824
See related
EnsemblRapid:ENSRNOG00000031662 AllianceGenome:RGD:621824
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GLYT2
Summary
Enables glycine:sodium symporter activity. Involved in glycine transport. Located in dense core granule and endosome. Is active in glycinergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 649.2) See more
Orthologs
human mouse all
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Genomic context

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See Slc6a5 in Genome Data Viewer
Location:
1q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (108767245..108833173)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (99645389..99697016)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (105270418..105336369)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene protein arginine methyltransferase 3 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 53 Neighboring gene neural EGFL like 1 Neighboring gene uncharacterized LOC120097222 Neighboring gene 60S ribosomal protein L31-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GlyT-2 mediates the forskolin-induced increase of glycinergic transmission. Nakamura M, et al. Neuroreport, 2010 Apr 21. PMID 20335821
  2. Glycine transporters are differentially expressed among CNS cells. Zafra F, et al. J Neurosci, 1995 May. PMID 7751957, Free PMC Article
  3. The second intracellular loop of the glycine transporter 2 contains crucial residues for glycine transport and phorbol ester-induced regulation. Fornés A, et al. J Biol Chem, 2004 May 28. PMID 15010455
  4. The neuronal glycine transporter GLYT2 associates with membrane rafts: functional modulation by lipid environment. Núñez E, et al. J Neurochem, 2008 Jun 1. PMID 18266927
  5. Subcellular localization of the neuronal glycine transporter GLYT2 in brainstem. Núñez E, et al. Traffic, 2009 Jul. PMID 19374720

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors.
    Title: Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors.
  2. The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.
    Title: The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.
  3. Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia.
    Title: Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia.
  4. Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain.
    Title: Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain.
  5. Phosphorylation of Serine 157 Protects the Rat Glycine Transporter GlyT2 from Calpain Cleavage.
    Title: Phosphorylation of Serine 157 Protects the Rat Glycine Transporter GlyT2 from Calpain Cleavage.
  6. E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2.
    Title: E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2.
  7. Following spinal cord transection there is a decrease in GlyT2 mRNA and GlyT2 protein expression.
    Title: Time-dependent, bidirectional, anti- and pro-spinal hyper-reflexia and muscle spasticity effect after chronic spinal glycine transporter 2 (GlyT2) oligonucleotide-induced downregulation.
  8. Results show that glycine transport by neuronal glycine transporter GlyT2 responds positively to treatments promoting pain signaling including ATP. GlyT2 is up-regulated upon stimulation of ATP-preferring P2X2/3 receptors in brainstem/spinal cord primary neuronal cultures in a paracrine manner causing a rapid increase of surface transporter and glycine transport.
    Title: P2X receptors up-regulate the cell-surface expression of the neuronal glycine transporter GlyT2.
  9. Study showed that glycine uptake mediated by GlyT1 and GlyT2 in astrocytes is modulated by BDNF
    Title: BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes.
  10. GlyT2 activity is pre-synaptically controlled by physical and functional association with plasma membrane PMCA2, PMCA3, and NCX1.
    Title: Presynaptic control of glycine transporter 2 (GlyT2) by physical and functional association with plasma membrane Ca2+-ATPase (PMCA) and Na+-Ca2+ exchanger (NCX).
Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter reuptake ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter uptake ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, glycinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, glycinergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in dense core granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glycinergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glycinergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sodium- and chloride-dependent glycine transporter 2
Names
glyT-2
glycine transporter 2
solute carrier family 6 (neurotransmitter transporter), member 5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203334.1 → NP_976079.1  sodium- and chloride-dependent glycine transporter 2

    See identical proteins and their annotated locations for NP_976079.1

    Status: PROVISIONAL

    Source sequence(s)
    L21672
    Related
    ENSRNOP00000043665.4, ENSRNOT00000041950.6
    Conserved Domains (1) summary
    cd11499
    Location:193 → 789
    SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    108767245..108833173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275140.1 → XP_063131210.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

    Related
    ENSRNOP00000105371.1, ENSRNOT00000170841.1

  2. XM_063275124.1 → XP_063131194.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

  3. XM_063275053.1 → XP_063131123.1  sodium- and chloride-dependent glycine transporter 2 isoform X1

  4. XM_063275237.1 → XP_063131307.1  sodium- and chloride-dependent glycine transporter 2 isoform X4

  5. XM_063275070.1 → XP_063131140.1  sodium- and chloride-dependent glycine transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    F1LNM6, P58295, Q6QDB3

  6. XM_063275456.1 → XP_063131526.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

  7. XM_063275160.1 → XP_063131230.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

  8. XM_063275211.1 → XP_063131281.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

  9. XM_063275413.1 → XP_063131483.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

  10. XM_063275262.1 → XP_063131332.1  sodium- and chloride-dependent glycine transporter 2 isoform X5

  11. XM_063275288.1 → XP_063131358.1  sodium- and chloride-dependent glycine transporter 2 isoform X6

  12. XM_063275351.1 → XP_063131421.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

  13. XM_063275372.1 → XP_063131442.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

  14. XM_063275437.1 → XP_063131507.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58295.2 GenPept UniProtKB/Swiss-Prot:P58295

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