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Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component [ Rattus norvegicus (Norway rat) ]

Gene ID: 171124, updated on 27-Nov-2024

Summary

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Official Symbol
Mms19provided by RGD
Official Full Name
MMS19 homolog, cytosolic iron-sulfur assembly componentprovided by RGD
Primary source
RGD:727890
See related
EnsemblRapid:ENSRNOG00000046769 AllianceGenome:RGD:727890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mms19l
Summary
Predicted to enable enzyme binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol; nucleoplasm; and spindle. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 86.8), Heart (RPKM 82.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mms19 in Genome Data Viewer
Location:
1q54
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (250706595..250743604, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (240757279..240794291, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (261191646..261229070, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene exosome component 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 16 Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin domain containing 1 Neighboring gene ankyrin repeat domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A compilation of partial sequences of randomly selected cDNA clones from the rat incisor. Matsuki Y, et al. J Dent Res, 1995 Jan. PMID 7876422
  2. The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor. Wu X, et al. J Biol Chem, 2001 Jun 29. PMID 11279242
  3. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD, et al. Biochim Biophys Acta, 2015 Jun. PMID 25583461
  4. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Ito S, et al. Mol Cell, 2010 Aug 27. PMID 20797633
  5. Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase. Weon JL, et al. Mol Cell, 2018 Jan 4. PMID 29225034

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by iron-sulfur cluster transfer ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MMXD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MMXD complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MMS19 nucleotide excision repair protein homolog
Names
MMS19 cytosolic iron-sulfur assembly component
MMS19 nucleotide excision repair homolog
MMS19 nucleotide excision repair-like
MMS19-like (MET18 homolog, S. cerevisiae)
incisor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271596.1 → NP_001258525.1  MMS19 nucleotide excision repair protein homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5Y1K6, M0R6T4
    Related
    ENSRNOP00000065140.1, ENSRNOT00000075531.4
    Conserved Domains (2) summary
    pfam12460
    Location:555 → 963
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:54 → 312
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    250706595..250743604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231382.4 → XP_006231444.1  MMS19 nucleotide excision repair protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y1K6
    Conserved Domains (2) summary
    pfam12460
    Location:554 → 962
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:54 → 312
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

  2. XM_039087880.2 → XP_038943808.1  MMS19 nucleotide excision repair protein homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y1K6
    Conserved Domains (2) summary
    pfam12460
    Location:511 → 919
    MMS19_C; RNAPII transcription regulator C-terminal
    pfam14500
    Location:47 → 268
    MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II

  3. XM_039087987.2 → XP_038943915.1  MMS19 nucleotide excision repair protein homolog isoform X3

    Conserved Domains (1) summary
    pfam12460
    Location:190 → 598
    MMS19_C; RNAPII transcription regulator C-terminal

RNA

  1. XR_005490967.2 RNA Sequence

  2. XR_010058213.1 RNA Sequence

  3. XR_005490966.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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