Grp gastrin releasing peptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grpprovided by RGD
Official Full Name: gastrin releasing peptideprovided by RGD
Primary source: RGD:621740
See related: EnsemblRapid:ENSRNOG00000016999 AllianceGenome:RGD:621740
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable neuropeptide hormone activity. Involved in several processes, including cellular response to sodium phosphate; negative regulation of cation channel activity; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in extracellular space. Is active in neuronal dense core vesicle. Biomarker of chronic kidney disease. Orthologous to human GRP (gastrin releasing peptide). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward (RPKM 43.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (61658655..61672037)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (59388679..59402061)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (61563458..61576818)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord.
Title: Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats.
feeding responses evoked by the large molecular form of gastrin releasing peptide (GRP) in the rat
Title: Sequence analysis and feeding responses evoked by the large molecular form of gastrin releasing peptide (GRP) in the rat GRP-29.
all forms of GRP reduce food intake in obese and lean adult Zucker rats similar to Bn in weanling rats.
Title: Obese and lean Zucker rats respond similarly to intraperitoneal administration of gastrin-releasing peptides.
The site of action of rat gastrin releasing peptide, in regulation of meal size and intermeal interval, is most likely the stomach and/or the duodenum.
Title: The stomach and/or upper duodenum contain sites of action that control meal size and intermeal interval length by exogenous rat gastrin releasing peptide.
Gastrin-releasing peptide terminals were found in spinal dorsal horn and trigeminal ganglion.
Title: Distribution of gastrin-releasing peptide in the rat trigeminal and spinal somatosensory systems.
GRP regulation of meal size and intermeal interval occurs at different sites in the rat.
Title: Intravenous infusion of gastrin-releasing peptide-27 and bombesin in rats reveals differential effects on meal size and intermeal interval length.
Gastrin-releasing peptide acts via postsynaptic bombesin type 2 receptors to modulate inward rectifier K+ and TRPV1-like conductances in rat paraventricular thalamic neurons
Title: Gastrin-releasing peptide acts via postsynaptic BB2 receptors to modulate inward rectifier K+ and TRPV1-like conductances in rat paraventricular thalamic neurons.
reduction of meal size and prolongation of intermeal interval (IMI) by GRP-29 require vagal and splanchnic nerves, and the duodenum is the major conduit that communicates prolongation of IMI by GRP-29 with the brain
Title: Gastrin releasing peptide-29 requires vagal and splanchnic neurons to evoke satiation and satiety.
With increasing levels of fear, levels of gastrin-releasing peptide (Grp) are increased in medial prefrontal cortex and basolateral amygdala.
Title: In vivo levels of corticotropin-releasing hormone and gastrin-releasing peptide at the basolateral amygdala and medial prefrontal cortex in response to conditioned fear in the rat.
GRP-29 and GRP-27 reduced the size of the first meal, prolonged intermeal interval and increased satiety ratio, but GRP-10 failed to exhibit similar feeding responses. The data support a role for GRP-29 in the short-term regulation of food intake.
Title: Gastrin releasing peptide-29 evokes feeding responses in the rat.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

Grp (e-PCR), detects polymorphism
- UniSTS:495914

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to sodium phosphate	IEP Inferred from Expression Pattern more info	PubMed
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of voltage-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavioral fear response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptide hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory gaseous exchange	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in psychomotor behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to external biotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule lumen	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: gastrin-releasing peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.