Mpc1 mitochondrial pyruvate carrier 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mpc1provided by RGD
Official Full Name: mitochondrial pyruvate carrier 1provided by RGD
Primary source: RGD:620902
See related: EnsemblRapid:ENSRNOG00000012415 AllianceGenome:RGD:620902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Brp44l; SLC54A1
Summary: Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within acetyl-CoA biosynthetic process from pyruvate and cellular response to leukemia inhibitory factor. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial pyruvate carrier deficiency. Orthologous to human MPC1 (mitochondrial pyruvate carrier 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 3557.4), Kidney (RPKM 2878.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (54985305..54996979, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (52437745..52449399, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (53026608..53038229, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aerobic exercise-induced HIF-1alpha upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
Title: Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats.
Title: Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats.
Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats.
Title: Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats.

Submit: New GeneRIF Correction

General gene information

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Markers

Brp44l (e-PCR), detects polymorphism
- UniSTS:226033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables pyruvate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to pyruvate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyruvate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA biosynthetic process from pyruvate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial pyruvate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial pyruvate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial pyruvate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial pyruvate carrier 1

Names: apoptosis-regulating basic protein; brain protein 44-like protein; solute carrier family 54 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133561.2 → NP_598245.1 mitochondrial pyruvate carrier 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P63031, Q4V8N5

Related

ENSRNOP00000017282.7, ENSRNOT00000017282.8

Conserved Domains (1) summary

pfam03650
Location:24 → 105

MPC; Uncharacterized protein family (UPF0041)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

54985305..54996979 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274096.1 → XP_063130166.1 mitochondrial pyruvate carrier 1 isoform X3

UniProtKB/Swiss-Prot

P63031, Q4V8N5
XM_063274062.1 → XP_063130132.1 mitochondrial pyruvate carrier 1 isoform X2

UniProtKB/TrEMBL

A6KK36
XM_039086663.2 → XP_038942591.1 mitochondrial pyruvate carrier 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZR29, A0A8L2Q8K1, A6KK31

Related

ENSRNOP00000080891.1, ENSRNOT00000105772.2

Conserved Domains (1) summary

pfam03650
Location:2 → 81

MPC; Uncharacterized protein family (UPF0041)
XM_063274001.1 → XP_063130071.1 mitochondrial pyruvate carrier 1 isoform X2

UniProtKB/TrEMBL

A6KK36