Acot12 acyl-CoA thioesterase 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acot12provided by RGD
Official Full Name: acyl-CoA thioesterase 12provided by RGD
Primary source: RGD:619752
See related: EnsemblRapid:ENSRNOG00000061414 AllianceGenome:RGD:619752
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cach; rACH
Summary: Enables acetyl-CoA hydrolase activity and identical protein binding activity. Involved in acyl-CoA metabolic process. Located in cytosol. Used to study liver cancer. Orthologous to human ACOT12 (acyl-CoA thioesterase 12). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Liver (RPKM 345.8) and Kidney (RPKM 71.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (24721648..24763686)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (22986867..23027538)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (20857056..20901656)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that cytosolic acetyl-CoA levels in the liver are controlled by lipid metabolites and hormones, which result in allosteric enzymatic and transcriptional regulation of ACOT12.
Title: Enzymatic and transcriptional regulation of the cytoplasmic acetyl-CoA hydrolase ACOT12.
acetyl-CoA-hydrolyzing activity in isolated mitochondria was induced by the treatment of rats with di(2-ehtylhexyl)phthalate (DEHP).
Title: Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase activity is demonstrated by 3-ketoacyl-CoA thiolase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables acetyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acetyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in acyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetyl-coenzyme A thioesterase

Names: CACH-1; acyl-CoA thioester hydrolase 12; acyl-coenzyme A thioesterase 12; cytoplasmic acetyl-CoA hydrolase 1; cytosolic acetyl-CoA hydrolase; rCACH-1

NP_570103.1

EC 3.1.2.1

XP_063137283.1

EC 3.1.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130747.1 → NP_570103.1 acetyl-coenzyme A thioesterase

See identical proteins and their annotated locations for NP_570103.1

Status: PROVISIONAL

Source sequence(s)

AB040609

UniProtKB/Swiss-Prot

Q99NB7

UniProtKB/TrEMBL

A6I4P8

Related

ENSRNOP00000075534.1, ENSRNOT00000078919.3

Conserved Domains (2) summary

cd03442
Location:178 → 296

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

cl14643
Location:312 → 547

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily