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Slc38a1 solute carrier family 38, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170567, updated on 4-Jan-2025

Summary

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Official Symbol
Slc38a1provided by RGD
Official Full Name
solute carrier family 38, member 1provided by RGD
Primary source
RGD:69645
See related
EnsemblRapid:ENSRNOG00000005291 AllianceGenome:RGD:69645
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ata1; GlnT; Sat1; Snat1
Summary
Enables alanine:sodium symporter activity; glycine:sodium symporter activity; and proline:sodium symporter activity. Involved in several processes, including amino acid import; glutamine metabolic process; and positive regulation of L-glutamine import across plasma membrane. Located in external side of apical plasma membrane and neuronal cell body. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SLC38A1 (solute carrier family 38 member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 285.3), Thymus (RPKM 191.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc38a1 in Genome Data Viewer
Location:
7q35
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (129612414..129681727, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (127733230..127802541, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (137970555..138040098, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093718 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ribosomal protein L10, pseudogene 13 Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene uncharacterized LOC134479562

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase A signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes. Ogura M, et al. J Cell Physiol, 2007 Aug. PMID 17323379
  2. Cloning and functional identification of a neuronal glutamine transporter. Varoqui H, et al. J Biol Chem, 2000 Feb 11. PMID 10660562
  3. Na+ transport by the neural glutamine transporter ATA1. Albers A, et al. Pflugers Arch, 2001 Oct. PMID 11692272
  4. Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons. Mackenzie B, et al. J Biol Chem, 2003 Jun 27. PMID 12684517
  5. Ontogeny of the neutral amino acid transporter SNAT1 in the developing rat. Weiss MD, et al. J Mol Histol, 2005 May. PMID 16200463

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming
    Title: Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.
  2. Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells
    Title: Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine.
  3. Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in rat cardiomyocytes.
    Title: Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in freshly isolated rat cardiomyocytes.
  4. SNAT1/SAT1 is the amino acid transporter system member that plays a critical role in dynamically modulating inhibition in response to metabolic demands.
    Title: Activity- and age-dependent modulation of GABAergic neurotransmission by system A-mediated glutamine uptake.
  5. SNAT1 protein expression decreased in the liver and intestine shortly after birth and as the rat matured; SNAT1 expression was constant throughout development in the lungs and kidney and increased in the heart from prenatal day 19 to postnatal day 2
    Title: Ontogeny of the neutral amino acid transporter SNAT1 in the developing rat.
  6. A high-capacity imino acid carrier localized at the small intestinal luminal membrane that transports nutrients and amino acids and imino acids.
    Title: H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat.
  7. Immunohistochemistry demonstrates the presence of SNAT1 within the placental labyrinth and within fetal endothelium.
    Title: SNAT expression in rat placenta.
  8. GlnT expression is upregulated by cyclic AMP/protein kinase A signals for subsequent exacerbation of the vulnerability to oxidative stress in astrocytes.
    Title: Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase A signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes.
  9. distribution of SNAT1 in central nervous system neurons and characterization of its transport properties
    Title: Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-glutamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alanine:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neutral L-amino acid:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables proline:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in alanine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid import IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in gamma-aminobutyric acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in gamma-aminobutyric acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glutamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of L-glutamine import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic transmission, GABAergic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in external side of apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-coupled neutral amino acid symporter 1
Names
N-system amino acid transporter 2
amino acid transporter A1
amino acid transporter system A1
glutamine transporter
rATA1
sodium-coupled neutral amino acid transporter 1
system A amino acid transporter 1
system A transporter 2
system N amino acid transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138832.1 → NP_620187.1  sodium-coupled neutral amino acid symporter 1

    See identical proteins and their annotated locations for NP_620187.1

    Status: PROVISIONAL

    Source sequence(s)
    AF075704
    UniProtKB/Swiss-Prot
    Q9JM15
    UniProtKB/TrEMBL
    A6KC24
    Related
    ENSRNOP00000008138.4, ENSRNOT00000008138.6
    Conserved Domains (1) summary
    cl00456
    Location:69 → 472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    129612414..129681727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242281.5 → XP_006242343.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006242343.1

    UniProtKB/Swiss-Prot
    Q9JM15
    UniProtKB/TrEMBL
    A6KC24
    Conserved Domains (1) summary
    cl00456
    Location:69 → 472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_063262935.1 → XP_063119005.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9JM15
    UniProtKB/TrEMBL
    A6KC24

  3. XM_006242280.5 → XP_006242342.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006242342.1

    UniProtKB/Swiss-Prot
    Q9JM15
    UniProtKB/TrEMBL
    A6KC24
    Conserved Domains (1) summary
    cl00456
    Location:69 → 472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_006242277.5 → XP_006242339.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006242339.1

    UniProtKB/Swiss-Prot
    Q9JM15
    UniProtKB/TrEMBL
    A6KC24
    Conserved Domains (1) summary
    cl00456
    Location:69 → 472
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. XM_063262936.1 → XP_063119006.1  sodium-coupled neutral amino acid symporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9JM15
    UniProtKB/TrEMBL
    A6KC24

  6. XM_039078321.2 → XP_038934249.1  sodium-coupled neutral amino acid symporter 1 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:3 → 341
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JM15.1 GenPept UniProtKB/Swiss-Prot:Q9JM15

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