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Lrrc23 leucine rich repeat containing 23 [ Mus musculus (house mouse) ]

Gene ID: 16977, updated on 27-Nov-2024

Summary

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Official Symbol
Lrrc23provided by MGI
Official Full Name
leucine rich repeat containing 23provided by MGI
Primary source
MGI:MGI:1315192
See related
Ensembl:ENSMUSG00000030125 AllianceGenome:MGI:1315192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B7; Lrpb7; 4921537K05Rik
Summary
Involved in flagellated sperm motility and radial spoke assembly. Located in sperm flagellum. Is active in cytosol. Is expressed in lung; lung epithelium; nasal cavity respiratory epithelium; nasal epithelium; and palatal shelf mesenchyme. Human ortholog(s) of this gene implicated in spermatogenic failure 92. Orthologous to human LRRC23 (leucine rich repeat containing 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 29.6), lung adult (RPKM 7.1) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Lrrc23 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124746832..124757411, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124769869..124780438, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8991 Neighboring gene atrophin 1 Neighboring gene STARR-seq mESC enhancer starr_17303 Neighboring gene enolase 2, gamma neuronal Neighboring gene predicted gene, 38895 Neighboring gene STARR-seq mESC enhancer starr_17308 Neighboring gene predicted gene, 38894 Neighboring gene STARR-positive B cell enhancer ABC_E2803 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility. Hwang JY, et al. Elife, 2023 Dec 13. PMID 38091523, Free PMC Article
  2. LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice. Zhang X, et al. J Cell Sci, 2021 Oct 15. PMID 34585727, Free PMC Article
  3. Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis. Piña JO, et al. Nat Commun, 2023 Sep 14. PMID 37709732, Free PMC Article
  4. Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Ansari-Lari MA, et al. Genome Res, 1998 Jan. PMID 9445485
  5. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility.
    Title: LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility.
  2. LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice.
    Title: LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice.
  3. Lrrc23 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
    Title: Tissue expression patterns identify mouse cilia genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in radial spoke assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat-containing protein 23
Names
leucine-rich protein B7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302555.1 → NP_001289484.1  leucine-rich repeat-containing protein 23

    See identical proteins and their annotated locations for NP_001289484.1

    Status: VALIDATED

    Source sequence(s)
    AW122764, BC049601
    Consensus CDS
    CCDS20528.1
    UniProtKB/Swiss-Prot
    O35125
    Related
    ENSMUSP00000108094.3, ENSMUST00000112475.9
    Conserved Domains (2) summary
    sd00033
    Location:70 → 89
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:75 → 281
    internalin_A; class 1 internalin InlA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124746832..124757411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241240.4 → XP_011239542.1  leucine-rich repeat-containing protein 23 isoform X2

    See identical proteins and their annotated locations for XP_011239542.1

    UniProtKB/Swiss-Prot
    O35125
    Conserved Domains (2) summary
    sd00033
    Location:70 → 89
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:75 → 281
    internalin_A; class 1 internalin InlA

  2. XM_006505659.5 → XP_006505722.1  leucine-rich repeat-containing protein 23 isoform X2

    See identical proteins and their annotated locations for XP_006505722.1

    UniProtKB/Swiss-Prot
    O35125
    Conserved Domains (2) summary
    sd00033
    Location:70 → 89
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:75 → 281
    internalin_A; class 1 internalin InlA

  3. XM_006505658.5 → XP_006505721.1  leucine-rich repeat-containing protein 23 isoform X1

    Conserved Domains (2) summary
    sd00033
    Location:100 → 119
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:105 → 311
    internalin_A; class 1 internalin InlA

  4. XM_006505660.5 → XP_006505723.1  leucine-rich repeat-containing protein 23 isoform X2

    See identical proteins and their annotated locations for XP_006505723.1

    UniProtKB/Swiss-Prot
    O35125
    Conserved Domains (2) summary
    sd00033
    Location:70 → 89
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:75 → 281
    internalin_A; class 1 internalin InlA

  5. XM_011241239.3 → XP_011239541.1  leucine-rich repeat-containing protein 23 isoform X2

    See identical proteins and their annotated locations for XP_011239541.1

    UniProtKB/Swiss-Prot
    O35125
    Related
    ENSMUSP00000032218.4, ENSMUST00000032218.10
    Conserved Domains (2) summary
    sd00033
    Location:70 → 89
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:75 → 281
    internalin_A; class 1 internalin InlA

  6. XM_006505663.5 → XP_006505726.1  leucine-rich repeat-containing protein 23 isoform X2

    See identical proteins and their annotated locations for XP_006505726.1

    UniProtKB/Swiss-Prot
    O35125
    Conserved Domains (2) summary
    sd00033
    Location:70 → 89
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:75 → 281
    internalin_A; class 1 internalin InlA

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_013588.1: Suppressed sequence

    Description
    NM_013588.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35125.1 GenPept UniProtKB/Swiss-Prot:O35125

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