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Kif9 kinesin family member 9 [ Mus musculus (house mouse) ]

Gene ID: 16578, updated on 27-Nov-2024

Summary

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Official Symbol
Kif9provided by MGI
Official Full Name
kinesin family member 9provided by MGI
Primary source
MGI:MGI:1098237
See related
Ensembl:ENSMUSG00000032489 AllianceGenome:MGI:1098237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and microtubule binding activity. Involved in regulation of flagellated sperm motility. Located in sperm flagellum. Is expressed in cochlea; hippocampus; lateral ventricle choroid plexus; metanephros; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human KIF9 (kinesin family member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 35.4) and lung adult (RPKM 1.2) See more
Orthologs
human all
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Genomic context

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See Kif9 in Genome Data Viewer
Location:
9 F2; 9 59.92 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110306062..110354242)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110476738..110525174)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kelch-like 18 Neighboring gene neutrophilic granule protein Neighboring gene STARR-positive B cell enhancer ABC_E8318 Neighboring gene STARR-seq mESC enhancer starr_25264 Neighboring gene SET domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_25267 Neighboring gene neurotrophin receptor associated death domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum. Miyata H, et al. Exp Anim, 2022 Feb 9. PMID 34526446, Free PMC Article
  2. Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility. Fang C, et al. J Cell Biol, 2024 Nov 4. PMID 39158699,
  3. Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa. Miyata H, et al. FASEB J, 2020 Apr. PMID 32072696, Free PMC Article
  4. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. Piddini E, et al. EMBO J, 2001 Aug 1. PMID 11483511, Free PMC Article
  5. NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins. Takano K, et al. Nucleic Acids Res, 2007. PMID 17403691, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility.
    Title: Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility.
  2. The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum.
    Title: The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141389

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF9
Names
kinesin 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163569.2 → NP_001157041.1  kinesin-like protein KIF9 isoform 1

    See identical proteins and their annotated locations for NP_001157041.1

    Status: VALIDATED

    Source sequence(s)
    AC132103
    Consensus CDS
    CCDS52938.1
    UniProtKB/TrEMBL
    Q3V3Y6, Q8C0X6
    Related
    ENSMUSP00000057896.7, ENSMUST00000061155.12
    Conserved Domains (1) summary
    cd01375
    Location:6 → 338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup

  2. NM_001411177.1 → NP_001398106.1  kinesin-like protein KIF9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132103
    UniProtKB/TrEMBL
    Q8C0X6

  3. NM_001411178.1 → NP_001398107.1  kinesin-like protein KIF9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132103
    UniProtKB/Swiss-Prot
    E9QMT7, O35070, Q9WV04

  4. NM_001411179.1 → NP_001398108.1  kinesin-like protein KIF9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132103

  5. NM_001411180.1 → NP_001398109.1  kinesin-like protein KIF9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132103

  6. NM_010628.4 → NP_034758.2  kinesin-like protein KIF9 isoform 2

    See identical proteins and their annotated locations for NP_034758.2

    Status: VALIDATED

    Source sequence(s)
    AC132103
    Consensus CDS
    CCDS23568.1
    UniProtKB/Swiss-Prot
    E9QMT7, O35070, Q9WV04
    UniProtKB/TrEMBL
    Q3V3Y6
    Related
    ENSMUSP00000082016.6, ENSMUST00000084952.8
    Conserved Domains (2) summary
    cd01375
    Location:6 → 338
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    pfam00225
    Location:12 → 340
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110306062..110354242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511944.3 → XP_006512007.1  kinesin-like protein KIF9 isoform X2

    See identical proteins and their annotated locations for XP_006512007.1

    UniProtKB/TrEMBL
    Q3V3Y6
    Conserved Domains (1) summary
    cd01375
    Location:20 → 352
    KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV04.2 GenPept UniProtKB/Swiss-Prot:Q9WV04

Gene LinkOut

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