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Kif12 kinesin family member 12 [ Mus musculus (house mouse) ]

Gene ID: 16552, updated on 27-Nov-2024

Summary

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Official Symbol
Kif12provided by MGI
Official Full Name
kinesin family member 12provided by MGI
Primary source
MGI:MGI:1098232
See related
Ensembl:ENSMUSG00000028357 AllianceGenome:MGI:1098232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in microtubule organizing center. Is expressed in embryo and inner cell mass. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human KIF12 (kinesin family member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 61.1), colon adult (RPKM 9.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Kif12 in Genome Data Viewer
Location:
4 B3; 4 33.96 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63076185..63090382, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63157948..63172145, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 618 Neighboring gene predicted gene, 30764 Neighboring gene alpha 1 microglobulin/bikunin precursor Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62883492-62883675 Neighboring gene collagen, type XXVII, alpha 1 Neighboring gene microRNA 455 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62968523-62968632 Neighboring gene STARR-seq mESC enhancer starr_10435 Neighboring gene predicted gene, 52743

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells. Yang W, et al. Dev Cell, 2014 Oct 27. PMID 25373778
  2. HNF-1beta regulates transcription of the PKD modifier gene Kif12. Gong Y, et al. J Am Soc Nephrol, 2009 Jan. PMID 19005009, Free PMC Article
  3. Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid. Jensen N, et al. Neurogenetics, 2016 Apr. PMID 26660102, Free PMC Article
  4. Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse. Mrug M, et al. PLoS One, 2015. PMID 26295839, Free PMC Article
  5. Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31. Mburu P, et al. Nat Genet, 2003 Aug. PMID 12833159

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kif12 is a candidate gene within the major polycystic kidney disease modifier 2 locus that modulates renal cystic disease severity in the Cys1cpk mouse.
    Title: Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse.
  2. the microtubule motor KIF12 mediates an antioxidant cascade in beta cells as an intracellular target of excess fat intake or "lipotoxicity."
    Title: Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.
  3. HNF-1beta regulates transcription of the PKD modifier gene Kif12.
    Title: HNF-1beta regulates transcription of the PKD modifier gene Kif12.
  4. Positional candidate gene, Kif12, fulfills the major criteria for quantitative trait loci gene discovery established by the Complex Trait Consortium, and, thus, it is proposed that Kif12 is a cpk modifier gene.
    Title: Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF12
Names
N-9 kinesin
kinesin 12
kinesin superfamily protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317352.1 → NP_001304281.1  kinesin-like protein KIF12 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL691496
    Consensus CDS
    CCDS89761.1
    UniProtKB/TrEMBL
    A0A097ZP89, A0A1Y7VK29
    Related
    ENSMUSP00000152690.2, ENSMUST00000156618.9
    Conserved Domains (3) summary
    cd00106
    Location:25 → 358
    KISc; Kinesin motor domain
    pfam00225
    Location:31 → 360
    Kinesin; Kinesin motor domain
    pfam12711
    Location:379 → 464
    Kinesin-relat_1; Kinesin motor

  2. NM_010616.3 → NP_034746.1  kinesin-like protein KIF12 isoform 2

    See identical proteins and their annotated locations for NP_034746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK018598, BP765257
    Consensus CDS
    CCDS18249.1
    UniProtKB/Swiss-Prot
    O35061, Q9D2Z8
    UniProtKB/TrEMBL
    A0A097ZP89
    Related
    ENSMUSP00000030042.3, ENSMUST00000030042.3
    Conserved Domains (3) summary
    cd00106
    Location:25 → 358
    KISc; Kinesin motor domain
    pfam00225
    Location:31 → 360
    Kinesin; Kinesin motor domain
    pfam12711
    Location:379 → 464
    Kinesin-relat_1; Kinesin motor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63076185..63090382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319998.3 → XP_017175487.1  kinesin-like protein KIF12 isoform X1

    UniProtKB/TrEMBL
    A0A097ZP89
    Conserved Domains (1) summary
    cd00106
    Location:25 → 358
    KISc; Kinesin motor domain

  2. XM_017319999.3 → XP_017175488.1  kinesin-like protein KIF12 isoform X2

    UniProtKB/TrEMBL
    A0A097ZP89
    Conserved Domains (1) summary
    cd00106
    Location:25 → 358
    KISc; Kinesin motor domain

  3. XM_017320000.2 → XP_017175489.1  kinesin-like protein KIF12 isoform X3

    Conserved Domains (1) summary
    cd00106
    Location:25 → 358
    KISc; Kinesin motor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2Z8.1 GenPept UniProtKB/Swiss-Prot:Q9D2Z8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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