Kcna6 potassium voltage-gated channel, shaker-related, subfamily, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcna6provided by MGI
Official Full Name: potassium voltage-gated channel, shaker-related, subfamily, member 6provided by MGI
Primary source: MGI:MGI:96663
See related: Ensembl:ENSMUSG00000038077 AllianceGenome:MGI:96663
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kv1.6; MK1.6
Summary: Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in axon terminus. Is expressed in several structures, including central nervous system; embryo mesenchyme; hindlimb muscle; neural retina; and trigeminal nerve. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 9.9), cortex adult (RPKM 8.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 61.72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (126685292..126717610, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (126708328..126740834, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteome landscape and interactome of voltage-gated potassium channel 1.6 (Kv1.6) of the murine ophthalmic artery and neuroretina.
Title: Proteome landscape and interactome of voltage-gated potassium channel 1.6 (Kv1.6) of the murine ophthalmic artery and neuroretina.
we are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting.
Title: Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcna6 (e-PCR), detects polymorphism
- UniSTS:143653

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 6

Names: voltage-gated potassium channel subunit Kv1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410072.1 → NP_001397001.1 potassium voltage-gated channel subfamily A member 6

Status: VALIDATED

Source sequence(s)

AC079438, AC124756

UniProtKB/Swiss-Prot

Q61923
NM_001410074.1 → NP_001397003.1 potassium voltage-gated channel subfamily A member 6

Status: VALIDATED

Source sequence(s)

AC079438, AC124756

UniProtKB/Swiss-Prot

Q61923

Related

ENSMUSP00000107861.2, ENSMUST00000112242.2
NM_001410075.1 → NP_001397004.1 potassium voltage-gated channel subfamily A member 6

Status: VALIDATED

Source sequence(s)

AC079438, AC124756

UniProtKB/Swiss-Prot

Q61923
NM_013568.7 → NP_038596.1 potassium voltage-gated channel subfamily A member 6

See identical proteins and their annotated locations for NP_038596.1

Status: VALIDATED

Source sequence(s)

AC079438, AC124756

Consensus CDS

CCDS20556.1

UniProtKB/Swiss-Prot

Q61923

Related

ENSMUSP00000036872.6, ENSMUST00000040751.6

Conserved Domains (2) summary

cd18407
Location:41 → 170

BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)

pfam00520
Location:258 → 468

Ion_trans; Ion transport protein