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ZFP1 ZFP1 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 162239, updated on 4-Jan-2025

Summary

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Official Symbol
ZFP1provided by HGNC
Official Full Name
ZFP1 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:23328
See related
Ensembl:ENSG00000184517 MIM:617230; AllianceGenome:HGNC:23328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF475
Summary
This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 4.0) and 24 other tissues See more
Orthologs
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Genomic context

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See ZFP1 in Genome Data Viewer
Location:
16q23.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (75119002..75172234)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (81165700..81218965)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75182422..75206132)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11115 Neighboring gene zinc and ring finger 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11116 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:75095860-75097059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:75108734-75109234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:75109235-75109735 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:75113000-75113201 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:75113937-75114482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:75121619-75122275 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:75127186-75127378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:75129219-75129949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:75129950-75130679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:75136275-75136776 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11122 Neighboring gene Sharpr-MPRA regulatory region 12749 Neighboring gene lactate dehydrogenase D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:75231710-75232210 Neighboring gene Sharpr-MPRA regulatory region 2157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7710 Neighboring gene RPS4Y1 pseudogene 1 Neighboring gene chymotrypsinogen B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. ZFP1 is a biomarker related to poor prognosis and immunity in gastric cancer. Yao J, et al. Sci Rep, 2024 Sep 11. PMID 39261568, Free PMC Article
  2. Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. Chowdhury K, et al. Nucleic Acids Res, 1989 Dec 25. PMID 2574853, Free PMC Article
  3. Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. Qiu GH, et al. Mol Ther, 2011 Aug. PMID 21540836, Free PMC Article
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. Dastani Z, et al. Eur J Hum Genet, 2010 Mar. PMID 19844255, Free PMC Article
  5. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Wolpin BM, et al. Nat Genet, 2014 Sep. PMID 25086665, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP1 is a biomarker related to poor prognosis and immunity in gastric cancer.
    Title: ZFP1 is a biomarker related to poor prognosis and immunity in gastric cancer.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ34243

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 1 homolog
Names
zinc finger protein 475

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318469.2 → NP_001305398.1  zinc finger protein 1 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK091562, BC033774, BC064604, BP219674, DC388176
    Consensus CDS
    CCDS10914.2
    UniProtKB/Swiss-Prot
    A8K5Q7, B4DKG9, Q6P2D0, Q8N188, Q8N9F9
    Related
    ENSP00000377080.2, ENST00000393430.6
    Conserved Domains (3) summary
    COG5048
    Location:146 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 47
    KRAB; KRAB box

  2. NM_001318471.2 → NP_001305400.1  zinc finger protein 1 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, BC033774, BC064604, BP219674, DC402593
    Consensus CDS
    CCDS82013.1
    UniProtKB/TrEMBL
    J3KNQ1
    Conserved Domains (2) summary
    COG5048
    Location:113 → 370
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001318472.2 → NP_001305401.1  zinc finger protein 1 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, AK308134, BC033774, BC064604, BP219674, DC388176
    Consensus CDS
    CCDS82013.1
    UniProtKB/TrEMBL
    J3KNQ1
    Related
    ENSP00000333192.4, ENST00000332307.4
    Conserved Domains (2) summary
    COG5048
    Location:113 → 370
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001318473.2 → NP_001305402.1  zinc finger protein 1 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, BC033774, BC064604, BP219674, DA781502, DC388176
    UniProtKB/Swiss-Prot
    Q6P2D0
    Conserved Domains (4) summary
    COG5048
    Location:91 → 348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:269 → 291
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:171 → 196
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001318474.2 → NP_001305403.1  zinc finger protein 1 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, BC033774, BC064604, BP219674, DC371394
    UniProtKB/Swiss-Prot
    Q6P2D0
    Conserved Domains (4) summary
    COG5048
    Location:91 → 348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:269 → 291
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:171 → 196
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001318475.2 → NP_001305404.1  zinc finger protein 1 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate splice site in the coding region, resulting in a frameshift and an early stop codon, compared to variant 1. Variants 7 and 8 encode the same isoform (4), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, AK094761, BC033774, BC064604, BP219674, BX647144, DB075594
    Consensus CDS
    CCDS82012.1
    UniProtKB/TrEMBL
    H3BV40
    Related
    ENSP00000455627.1, ENST00000567481.1
    Conserved Domains (1) summary
    smart00349
    Location:8 → 48
    KRAB; krueppel associated box

  7. NM_001318476.2 → NP_001305405.1  zinc finger protein 1 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the coding region, resulting in a frameshift and an early stop codon, compared to variant 1. Variants 7 and 8 encode the same isoform (4), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, AK094761, BC033774, BC064604, BP219674, BX647144, DC388176
    Consensus CDS
    CCDS82012.1
    UniProtKB/TrEMBL
    H3BV40
    Related
    ENSP00000457941.1, ENST00000464850.5
    Conserved Domains (1) summary
    smart00349
    Location:8 → 48
    KRAB; krueppel associated box

  8. NM_153688.4 → NP_710155.2  zinc finger protein 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_710155.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK091562, AK296560, BC033774, BC064604, BP219674, DC388176
    Consensus CDS
    CCDS10914.2
    UniProtKB/Swiss-Prot
    A8K5Q7, B4DKG9, Q6P2D0, Q8N188, Q8N9F9
    Related
    ENSP00000457044.1, ENST00000570010.6
    Conserved Domains (3) summary
    COG5048
    Location:146 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 47
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    75119002..75172234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522921.3 → XP_011521223.1  zinc finger protein 1 homolog isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:34 → 74
    KRAB; krueppel associated box
    COG5048
    Location:172 → 429
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:350 → 372
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:34 → 73
    KRAB; KRAB box
    pfam13465
    Location:252 → 277
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047433668.1 → XP_047289624.1  zinc finger protein 1 homolog isoform X1

  3. XM_024450168.2 → XP_024305936.1  zinc finger protein 1 homolog isoform X4

    UniProtKB/TrEMBL
    H3BV40
    Conserved Domains (1) summary
    smart00349
    Location:8 → 48
    KRAB; krueppel associated box

  4. XM_047433669.1 → XP_047289625.1  zinc finger protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    A8K5Q7, B4DKG9, Q6P2D0, Q8N188, Q8N9F9

  5. XM_047433670.1 → XP_047289626.1  zinc finger protein 1 homolog isoform X3

    UniProtKB/TrEMBL
    J3KNQ1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654723.1 Reference GRCh38.p14 PATCHES

    Range
    1..2424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    81165700..81218965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379708.1 → XP_054235683.1  zinc finger protein 1 homolog isoform X2

  2. XM_054379710.1 → XP_054235685.1  zinc finger protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    A8K5Q7, B4DKG9, Q6P2D0, Q8N188, Q8N9F9

  3. XM_054379711.1 → XP_054235686.1  zinc finger protein 1 homolog isoform X3

  4. XM_054379709.1 → XP_054235684.1  zinc finger protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    A8K5Q7, B4DKG9, Q6P2D0, Q8N188, Q8N9F9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P2D0.2 GenPept UniProtKB/Swiss-Prot:Q6P2D0

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