Il5 interleukin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il5provided by MGI
Official Full Name: interleukin 5provided by MGI
Primary source: MGI:MGI:96557
See related: Ensembl:ENSMUSG00000036117 AllianceGenome:MGI:96557
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il-5
Summary: Enables cytokine activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in colon; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma and stomach cancer. Orthologous to human IL5 (interleukin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.99 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (53611621..53615930)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (53720794..53725103)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of IL-5 in asthma and airway remodelling.
Title: Role of IL-5 in asthma and airway remodelling.
Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice.
Title: Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice.
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Title: Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
IL-5-producing CD4[+] T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer.
Title: IL-5-producing CD4(+) T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer.
Interleukin-5-induced eosinophil population improves cardiac function after myocardial infarction.
Title: Interleukin-5-induced eosinophil population improves cardiac function after myocardial infarction.
IL-5 enhances the resistance of Actinobacillus pleuropneumoniae infection in mice through maintaining appropriate levels of lung M2, PMN-II and highly effective neutrophil extracellular traps.
Title: IL-5 enhances the resistance of Actinobacillus pleuropneumoniae infection in mice through maintaining appropriate levels of lung M2, PMN-II and highly effective neutrophil extracellular traps.
Deletion of Arno Reduces Eosinophilic Inflammation and Interleukin-5 Expression in a Murine Model of Rhinitis.
Title: Deletion of Arno Reduces Eosinophilic Inflammation and Interleukin-5 Expression in a Murine Model of Rhinitis.
Beyond Il-5: Metabolic Reprogramming and Stromal Support Are Prerequisite for Generation and Survival of Long-Lived Eosinophil.
Title: Beyond Il-5: Metabolic Reprogramming and Stromal Support Are Prerequisite for Generation and Survival of Long-Lived Eosinophil.
Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration.
Title: Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration.
Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells.
Title: Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha2919 (e-PCR)
- UniSTS:515610

NoName (e-PCR)
- UniSTS:484902

Il5 (e-PCR), detects polymorphism
- UniSTS:463950

X06271 (e-PCR)
- UniSTS:125791

NoName (e-PCR)
- UniSTS:495491

D618 (e-PCR)
- UniSTS:124842

X06271 (e-PCR)
- UniSTS:163499

Il5 (e-PCR), detects polymorphism
- UniSTS:143569

Il5 (e-PCR), detects polymorphism
- UniSTS:143570

Il5 (e-PCR), detects polymorphism
- UniSTS:143571

Il5 (e-PCR), detects polymorphism
- UniSTS:143572

D11Nds9 (e-PCR), detects polymorphism
- UniSTS:141782

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-5 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-5 receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-5-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eosinophil differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of eosinophil differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-5

Names: B-cell growth factor II; BCGF-II; T-cell replacing factor; TRF; cytotoxic T-lymphocyte inducer; eosinophil differentiation factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.