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Il1r1 interleukin 1 receptor, type I [ Mus musculus (house mouse) ]

Gene ID: 16177, updated on 27-Nov-2024

Summary

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Official Symbol
Il1r1provided by MGI
Official Full Name
interleukin 1 receptor, type Iprovided by MGI
Primary source
MGI:MGI:96545
See related
Ensembl:ENSMUSG00000026072 AllianceGenome:MGI:96545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-iR; CD121a; CD121b; IL-1R1; Il1r-1; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha
Summary
Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in aorta-gonad-mesonephros; brain; liver; spleen; and uterus. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E18 (RPKM 5.6), bladder adult (RPKM 4.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Il1r1 in Genome Data Viewer
Location:
1 B; 1 18.81 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40261651..40355361)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40222480..40316201)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:40142581-40142881 Neighboring gene predicted gene, 16894 Neighboring gene STARR-seq mESC enhancer starr_00736 Neighboring gene interleukin 1 receptor, type II Neighboring gene predicted gene, 35741 Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene STARR-seq mESC enhancer starr_00738 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 1 receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_00741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of interleukin (IL)-1 type 1 receptor in mycobacterial infection. Sugawara I, et al. Microbiol Immunol, 2001. PMID 11791667
  2. Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice. Johnston RA, et al. Am J Respir Cell Mol Biol, 2007 Oct. PMID 17575079, Free PMC Article
  3. β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1. Moorlag SJCFM, et al. Cell Rep, 2020 May 19. PMID 32433977, Free PMC Article
  4. Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress. DiSabato DJ, et al. Mol Psychiatry, 2021 Sep. PMID 32444870, Free PMC Article
  5. The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model. Schmitz N, et al. Eur J Immunol, 2003 Apr. PMID 12672065

See all (809) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4[+] T cell responses following COVID-19 mRNA vaccination.
    Title: IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4(+) T cell responses following COVID-19 mRNA vaccination.
  2. M1-Type Microglia-Derived Extracellular Vesicles Overexpressing IL-1R1 Promote Postoperative Cognitive Dysfunction by Regulating Neuronal Inflammation.
    Title: M1-Type Microglia-Derived Extracellular Vesicles Overexpressing IL-1R1 Promote Postoperative Cognitive Dysfunction by Regulating Neuronal Inflammation.
  3. IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury.
    Title: IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury.
  4. Cumulus Cells Accelerate Postovulatory Oocyte Aging through IL1-IL1R1 Interaction in Mice.
    Title: Cumulus Cells Accelerate Postovulatory Oocyte Aging through IL1-IL1R1 Interaction in Mice.
  5. IL-1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis.
    Title: IL-1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis.
  6. Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice.
    Title: Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice.
  7. The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.
    Title: The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.
  8. IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.
    Title: IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.
  9. IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
    Title: IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
  10. Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress.
    Title: Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress.
Submit: New GeneRIF Correction See all GeneRIFs (151)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129154

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-1 receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables interleukin-1 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heat acclimation ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 1 cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 1 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neutrophil extravasation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-1 receptor type 1
Names
CD121 antigen-like family member A
IL-1 receptor alpha chain
interleukin-1 receptor alpha
NP_001116854.1
NP_032388.1
XP_006495776.1
XP_006495777.1
XP_006495785.1
XP_006495786.1
XP_030106479.1
XP_036018058.1
XP_036018071.1
XP_036018078.1
XP_036018079.1
XP_036018081.1
XP_036018088.1
XP_036018090.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123382.2 → NP_001116854.1  interleukin-1 receptor type 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001116854.1

    Status: VALIDATED

    Source sequence(s)
    AC135085, AC167168
    Consensus CDS
    CCDS48246.1
    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Related
    ENSMUSP00000110443.2, ENSMUST00000114795.3
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  2. NM_008362.3 → NP_032388.1  interleukin-1 receptor type 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032388.1

    Status: VALIDATED

    Source sequence(s)
    AC135085, AC167168
    Consensus CDS
    CCDS35547.1
    UniProtKB/Swiss-Prot
    P13504
    UniProtKB/TrEMBL
    Q32MH0, Q8C6P3
    Related
    ENSMUSP00000027241.5, ENSMUST00000027241.11
    Conserved Domains (4) summary
    smart00255
    Location:387 → 542
    TIR; Toll - interleukin 1 - resistance
    cd05757
    Location:131 → 220
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    pfam13927
    Location:229 → 319
    Ig_3; Immunoglobulin domain
    cl11960
    Location:31 → 116
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40261651..40355361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495713.4 → XP_006495776.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006495776.1

    UniProtKB/Swiss-Prot
    P13504
    UniProtKB/TrEMBL
    Q32MH0, Q8C6P3
    Conserved Domains (4) summary
    smart00255
    Location:387 → 542
    TIR; Toll - interleukin 1 - resistance
    cd05757
    Location:131 → 220
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    pfam13927
    Location:229 → 319
    Ig_3; Immunoglobulin domain
    cl11960
    Location:31 → 116
    Ig; Immunoglobulin domain

  2. XM_006495722.4 → XP_006495785.1  interleukin-1 receptor type 1 isoform X2

    See identical proteins and their annotated locations for XP_006495785.1

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  3. XM_030250619.2 → XP_030106479.1  interleukin-1 receptor type 1 isoform X2

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  4. XM_036162185.1 → XP_036018078.1  interleukin-1 receptor type 1 isoform X2

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  5. XM_036162197.1 → XP_036018090.1  interleukin-1 receptor type 1 isoform X2

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  6. XM_036162186.1 → XP_036018079.1  interleukin-1 receptor type 1 isoform X2

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  7. XM_006495723.5 → XP_006495786.1  interleukin-1 receptor type 1 isoform X2

    See identical proteins and their annotated locations for XP_006495786.1

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  8. XM_036162195.1 → XP_036018088.1  interleukin-1 receptor type 1 isoform X2

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  9. XM_036162178.1 → XP_036018071.1  interleukin-1 receptor type 1 isoform X2

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  10. XM_036162165.1 → XP_036018058.1  interleukin-1 receptor type 1 isoform X2

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  11. XM_006495714.5 → XP_006495777.1  interleukin-1 receptor type 1 isoform X2

    See identical proteins and their annotated locations for XP_006495777.1

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain

  12. XM_036162188.1 → XP_036018081.1  interleukin-1 receptor type 1 isoform X2

    UniProtKB/TrEMBL
    Q8C6P3, Q8C833
    Conserved Domains (3) summary
    smart00255
    Location:384 → 539
    TIR; Toll - interleukin 1 - resistance
    cd00096
    Location:226 → 229
    Ig; Ig strand A [structural motif]
    cl11960
    Location:226 → 329
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13504.1 GenPept UniProtKB/Swiss-Prot:P13504

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