Casp12 caspase 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Casp12provided by RGD
Official Full Name: caspase 12provided by RGD
Primary source: RGD:621758
See related: EnsemblRapid:ENSRNOG00000033434 AllianceGenome:RGD:621758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cysteine-type peptidase activity; endopeptidase activity; and protease binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of striated muscle cell apoptotic process; and protein autoprocessing. Predicted to be located in endoplasmic reticulum. Predicted to be part of NLRP1 inflammasome complex. Predicted to be active in cytosol. Used to study sciatic neuropathy. Biomarker of several diseases, including diabetes mellitus (multiple); heart disease (multiple); neurodegenerative disease (multiple); post-traumatic stress disorder; and ureteral obstruction. Orthologous to human CASP12 (caspase 12 (gene/pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 149.4), Liver (RPKM 106.3) and 8 other tissues See more
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Genomic context

Location:: 8q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (10927188..10954442)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (2642296..2669549)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (2658892..2686160)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results suggest that emodin inhibits SIRS in rats with SAP by inducing circulating neutrophil apoptosis via the Ca(2+)-calpain 1-caspase 12-caspase 3 signaling pathway
Title: Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca(2+)-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis.
caspase-12 plays an important role in stretch-induced apoptosis that is associated by endoplasmic reticulum stress by activating caspase-3.
Title: Caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress.
Tauroursodeoxycholic acid inhibits the expression of caspase-12 in rat neurons after spinal cord injury, reducing apoptosis and exerting neuroprotective effects.
Title: Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats.
Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Title: ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
This study demonstred that caspase-12 mRNA in the hippocampus was elevated in subarachnoid hemorrhage animals.
Title: Correlation between nitric oxide and early brain injury after subarachnoid hemorrhage.
SMI could alleviate myocardial ER stress and caspase-12 dependent apoptosis, which subsequently helped to improve the heart function of rats with DOX-CM.
Title: Shengmai injection improved doxorubicin-induced cardiomyopathy by alleviating myocardial endoplasmic reticulum stress and caspase-12 dependent apoptosis.
Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis is mediated by calcium/JNK/P38 MAPK and calpain/caspase-12 signaling pathways.
Title: Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathways.
Lipoxin A4 could play a role in myocardial protection via a mechanism related to downregulation of GRP-78 and caspase-12, and inhibition of apoptosis.
Title: LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats.
Results showed that, following thapsigargin treatment, more Purkinje neuron dendrites in the ethanol-fed group expressed activated caspase 12
Title: ATF6 and caspase 12 expression in Purkinje neurons in acute slices from adult, ethanol-fed rats.
PERK pathway of the unfolded protein response (UPR) is involved in glucose deprivation (GD)-induced apoptotic neuronal death through the activation of caspase-12, rather than the mitochondrial-dependent caspase pathway.
Title: Glucose deprivation induces reticulum stress by the PERK pathway and caspase-7- and calpain-mediated caspase-12 activation.

Submit: New GeneRIF Correction See all GeneRIFs (31)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	NAS Non-traceable Author Statement more info	PubMed
involved_in luteolysis	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of striated muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to anoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron(III) ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to kainic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in self proteolysis	IEA Inferred from Electronic Annotation more info
involved_in self proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLRP1 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-12

Names: CASP-12

NP_569106.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130422.2 → NP_569106.1 caspase-12

See identical proteins and their annotated locations for NP_569106.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q920D5

UniProtKB/TrEMBL

F1LNW4

Related

ENSRNOP00000010244.7, ENSRNOT00000010243.7

Conserved Domains (2) summary

smart00115
Location:167 → 418

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08325
Location:6 → 88

CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins