Slc36a1 solute carrier family 36 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc36a1provided by RGD
Official Full Name: solute carrier family 36 member 1provided by RGD
Primary source: RGD:619801
See related: EnsemblRapid:ENSRNOG00000065424 AllianceGenome:RGD:619801
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lyaat1
Summary: Enables neutral L-amino acid transmembrane transporter activity and proline:proton symporter activity. Involved in neutral amino acid transport and proton transmembrane transport. Located in lysosome and plasma membrane. Orthologous to human SLC36A1 (solute carrier family 36 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 49.3), Kidney (RPKM 36.5) and 9 other tissues See more
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Genomic context

Location:: 10q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (39819753..39858068)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (39319062..39357374)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (40538013..40573304)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sertraline is an apparent non-competitive inhibitor of PAT1-mediated transport.
Title: Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro.
knockdown of (PAT1) led to induced cellular growth, suggesting a role for PAT1 in regulating cellular proliferation of smooth muscle cells
Title: PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats.
Expression of proton-assisted amino acid transporter 1 (PAT1) mRNA was slightly but not significantly induced by a single bout of exercise in soleus and extensor digitorum longus muscles.
Title: Induction of amino acid transporters expression by endurance exercise in rat skeletal muscle.
PAT1(Slc36a1) protein was present in rat rectal epithelium.
Title: Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PAT1, Slc36a1), in rats.
The essential role of chloride and fructose absorbing Slc36a1 is reported.
Title: Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5.
The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons.
Title: The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

AW534070 (e-PCR)
- UniSTS:246544

C14M90 (e-PCR)
- UniSTS:76028

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-proline transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-proline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-proline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables L-tyrosine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glycine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed
enables proline:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proline:proton symporter activity	IEA Inferred from Electronic Annotation more info
enables proline:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-alanine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-alanine transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-alanine transport	ISO Inferred from Sequence Orthology more info
involved_in alanine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glycine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycine transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proline transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proline transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proline transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in taurine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in taurine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proton-coupled amino acid transporter 1

Names: LYAAT-1; lysosomal amino acid transporter 1; neutral amino acid/proton symporter; proton/amino acid transporter 1; solute carrier family 36 (proton/amino acid symporter), member 1; ysosomal amino acid transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130415.2 → NP_569099.1 proton-coupled amino acid transporter 1

See identical proteins and their annotated locations for NP_569099.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q924A5

UniProtKB/TrEMBL

A0A8L2R9L5, A6HEL6

Related

ENSRNOP00000016755.3, ENSRNOT00000016755.7

Conserved Domains (1) summary

cl00456
Location:47 → 452

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

39819753..39858068

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268355.1 → XP_063124425.1 proton-coupled amino acid transporter 1 isoform X1

UniProtKB/Swiss-Prot

Q924A5

UniProtKB/TrEMBL

A6HEL6
XM_008767659.2 → XP_008765881.1 proton-coupled amino acid transporter 1 isoform X1

See identical proteins and their annotated locations for XP_008765881.1

UniProtKB/Swiss-Prot

Q924A5

UniProtKB/TrEMBL

A0A8L2R9L5, A6HEL6

Conserved Domains (1) summary

cl00456
Location:47 → 452

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain