Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpa1provided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein A1provided by MGI
Primary source: MGI:MGI:104820
See related: Ensembl:ENSMUSG00000046434 AllianceGenome:MGI:104820
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hdp; HDP-1; Hnrpa1; hnRNP A1; hnrnp-A1
Summary: Predicted to enable identical protein binding activity; nucleic acid binding activity; and protein domain specific binding activity. Acts upstream of or within alternative mRNA splicing, via spliceosome. Located in nucleus. Is active in synapse. Is expressed in several structures, including 1-cell stage embryo; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; distal myopathy 3; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 643.9), CNS E14 (RPKM 307.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 58.58 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (103148840..103155119)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (103239943..103246698)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

m[6]A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis.
Title: m(6)A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis.
Adipocyte-Specific Hnrnpa1 Knockout Aggravates Obesity-Induced Metabolic Dysfunction via Upregulation of CCL2.
Title: Adipocyte-Specific Hnrnpa1 Knockout Aggravates Obesity-Induced Metabolic Dysfunction via Upregulation of CCL2.
Phosphorylation of hnRNP A1-Serine 199 Is Not Required for T Cell Differentiation and Function.
Title: Phosphorylation of hnRNP A1-Serine 199 Is Not Required for T Cell Differentiation and Function.
Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity.
Title: Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity.
hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.
Title: hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.
HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.
Title: HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.
hnRNP A1 dysfunction in oligodendrocytes contributes to the pathogenesis of multiple sclerosis.
Title: hnRNP A1 dysfunction in oligodendrocytes contributes to the pathogenesis of multiple sclerosis.
hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
Title: hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells.
Title: Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells.
HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis.
Title: HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hnrpa1 (e-PCR), detects polymorphism
- UniSTS:479118

RH126030 (e-PCR)
- UniSTS:162742

UniSTS:479162 (e-PCR)
- UniSTS:479162

Hnrpa1 (e-PCR), detects polymorphism
- UniSTS:479162

PMC137566P1 (e-PCR)
- UniSTS:270842

Clone Names

MGC102127, MGC102128, MGC103392, D15Ertd119e

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA/DNA annealing activity	ISO Inferred from Sequence Orthology more info
enables G-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA strand annealing activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables telomeric repeat-containing RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	ISS Inferred from Sequence or Structural Similarity more info
involved_in import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear export	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasmic periphery of the nuclear pore complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein A1

Names: helix-destabilizing protein; hnRNP core protein A1; single-strand-binding protein; topoisomerase-inhibitor suppressed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039129.5 → NP_001034218.1 heterogeneous nuclear ribonucleoprotein A1 isoform b

See identical proteins and their annotated locations for NP_001034218.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (b).

Source sequence(s)

AC164069

Consensus CDS

CCDS37232.1

UniProtKB/TrEMBL

Q3U7F3, Q5EBP8

Related

ENSMUSP00000042658.10, ENSMUST00000036004.16

Conserved Domains (3) summary

cd12580
Location:105 → 181

RRM2_hnRNPA1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

cd12761
Location:12 → 92

RRM1_hnRNPA1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

pfam11627
Location:310 → 345

HnRNPA1; Nuclear factor hnRNPA1
NM_010447.6 → NP_034577.1 heterogeneous nuclear ribonucleoprotein A1 isoform a

See identical proteins and their annotated locations for NP_034577.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an in-frame exon in the central coding region, compared to variant 2. The encoded isoform (a) is shorter, compared to isoform b.

Source sequence(s)

AC164069

Consensus CDS

CCDS37233.1

UniProtKB/Swiss-Prot

P49312, P97312, Q3V269

UniProtKB/TrEMBL

Q3TFB1

Related

ENSMUSP00000084609.8, ENSMUST00000087351.9

Conserved Domains (3) summary

pfam11627
Location:255 → 292

HnRNPA1; Nuclear factor hnRNPA1

cd12582
Location:105 → 184

RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

cd12761
Location:12 → 92

RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

RNA

NR_104427.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 3' exon structure, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC164069
NR_177200.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate 3' exon structure, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC164069