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SLC16A14 solute carrier family 16 member 14 [ Homo sapiens (human) ]

Gene ID: 151473, updated on 27-Nov-2024

Summary

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Official Symbol
SLC16A14provided by HGNC
Official Full Name
solute carrier family 16 member 14provided by HGNC
Primary source
HGNC:HGNC:26417
See related
Ensembl:ENSG00000163053 AllianceGenome:HGNC:26417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT14
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in skin (RPKM 4.6), brain (RPKM 4.6) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See SLC16A14 in Genome Data Viewer
Location:
2q36.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230034982..230068924, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (230517639..230551553, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230899698..230933640, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373924 Neighboring gene F-box protein 36 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:230829825-230830039 Neighboring gene RNA, U6 small nuclear 1027, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:230871505-230871694 Neighboring gene uncharacterized LOC107985996 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:230910722-230911921 Neighboring gene uncharacterized LOC107985995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230932348-230933118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17208 Neighboring gene RNY4 pseudogene 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231005392-231005920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12407 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:231044589-231045131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17209 Neighboring gene SP110 nuclear body protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17210 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:231084625-231084811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17215 Neighboring gene SP140 nuclear body protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231129497-231130018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12408 Neighboring gene MPRA-validated peak4075 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:231176974-231178173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231206345-231206936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17219 Neighboring gene SP140 nuclear body protein like Neighboring gene uncharacterized LOC105373925

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney. Roshanbin S, et al. BMC Neurosci, 2016 Jul 1. PMID 27364523, Free PMC Article
  2. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Halestrap AP, et al. Pflugers Arch, 2004 Feb. PMID 12739169
  3. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Malik S, et al. Cell Cycle, 2016 Aug 17. PMID 27433848, Free PMC Article
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monocarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 14
Names
MCT 14
monocarboxylic acid transporter 14
solute carrier family 16 (monocarboxylic acid transporters), member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152527.5 → NP_689740.2  monocarboxylate transporter 14

    See identical proteins and their annotated locations for NP_689740.2

    Status: VALIDATED

    Source sequence(s)
    AL833470, BC065524, DA044472
    Consensus CDS
    CCDS2473.1
    UniProtKB/Swiss-Prot
    A8KA08, Q53R92, Q7RTX9, Q96NI7
    UniProtKB/TrEMBL
    Q6ZWE5
    Related
    ENSP00000295190.4, ENST00000295190.9
    Conserved Domains (1) summary
    cl26868
    Location:24 → 490
    2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    230034982..230068924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246353.5 → XP_005246410.1  monocarboxylate transporter 14 isoform X3

    UniProtKB/TrEMBL
    Q6ZWE5
    Conserved Domains (2) summary
    cd06174
    Location:260 → 442
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:24 → 442
    2A0113; monocarboxylate transporter 1

  2. XM_047443523.1 → XP_047299479.1  monocarboxylate transporter 14 isoform X3

  3. XM_017003480.3 → XP_016858969.1  monocarboxylate transporter 14 isoform X1

    UniProtKB/Swiss-Prot
    A8KA08, Q53R92, Q7RTX9, Q96NI7
    UniProtKB/TrEMBL
    Q6ZWE5
    Conserved Domains (1) summary
    cl26868
    Location:24 → 490
    2A0111; oxalate/formate antiporter family transporter

  4. XM_011510751.4 → XP_011509053.1  monocarboxylate transporter 14 isoform X1

    See identical proteins and their annotated locations for XP_011509053.1

    UniProtKB/Swiss-Prot
    A8KA08, Q53R92, Q7RTX9, Q96NI7
    UniProtKB/TrEMBL
    Q6ZWE5
    Conserved Domains (1) summary
    cl26868
    Location:24 → 490
    2A0111; oxalate/formate antiporter family transporter

  5. XM_011510752.3 → XP_011509054.1  monocarboxylate transporter 14 isoform X2

    UniProtKB/TrEMBL
    Q6ZWE5
    Related
    ENSP00000400352.1, ENST00000457406.5
    Conserved Domains (2) summary
    cd06174
    Location:37 → 461
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:41 → 457
    MFS_1; Major Facilitator Superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    230517639..230551553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340806.1 → XP_054196781.1  monocarboxylate transporter 14 isoform X3

  2. XM_054340807.1 → XP_054196782.1  monocarboxylate transporter 14 isoform X3

  3. XM_054340803.1 → XP_054196778.1  monocarboxylate transporter 14 isoform X1

    UniProtKB/Swiss-Prot
    A8KA08, Q53R92, Q7RTX9, Q96NI7

  4. XM_054340804.1 → XP_054196779.1  monocarboxylate transporter 14 isoform X1

    UniProtKB/Swiss-Prot
    A8KA08, Q53R92, Q7RTX9, Q96NI7

  5. XM_054340805.1 → XP_054196780.1  monocarboxylate transporter 14 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7RTX9.1 GenPept UniProtKB/Swiss-Prot:Q7RTX9

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