Hbb-y hemoglobin Y, beta-like embryonic chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hbb-yprovided by MGI
Official Full Name: hemoglobin Y, beta-like embryonic chainprovided by MGI
Primary source: MGI:MGI:96027
See related: Ensembl:ENSMUSG00000052187 AllianceGenome:MGI:96027
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ey; Hby
Summary: Predicted to enable several functions, including heme binding activity; hemoglobin alpha binding activity; and oxygen binding activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in several structures, including blood; extraembryonic component; genitourinary system; limb; and nervous system. Human ortholog(s) of this gene implicated in delta beta-thalassemia and sickle cell anemia. Orthologous to several human genes including HBE1 (hemoglobin subunit epsilon 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 8232.3) and CNS E11.5 (RPKM 3742.4) See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 54.85 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (103500961..103502414, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (103851754..103853207, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study showed that increased fetal hemoglobin expression, or use of agents which improve fetal hemoglobin expression, increases osteoblast bone differentiation in association with decreased inflammatory cytokine release
Title: Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis.
KAP-1 may contribute to the repression of Ey and beta-major globin gene transcription through recruitment to the promoters of these two genes, mediated by the interaction of KAP-1 with either Zfp445 or MafK, respectively
Title: Identification of KAP-1-associated complexes negatively regulating the Ey and β-major globin genes in the β-globin locus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hbb-y (e-PCR), detects polymorphism
- UniSTS:531473

PMC139749P1 (e-PCR)
- UniSTS:270888

PMC139749P4 (e-PCR)
- UniSTS:270891

Hbb-y (e-PCR), detects polymorphism
- UniSTS:256865

Hbb-y (e-PCR), detects polymorphism
- UniSTS:474749

PMC141148P2 (e-PCR)
- UniSTS:270991

PMC86936P1 (e-PCR)
- UniSTS:273560

Hbb-y (e-PCR), detects polymorphism
- UniSTS:516511

Hbb-y (e-PCR), detects polymorphism
- UniSTS:256674

Hbb-y (e-PCR), detects polymorphism
- UniSTS:499135

Hbb-y (e-PCR), detects polymorphism
- UniSTS:516564

PMC21968P1 (e-PCR)
- UniSTS:272086

Hbb-y (e-PCR), detects polymorphism
- UniSTS:259552

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to haptoglobin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables hemoglobin alpha binding	IBA Inferred from Biological aspect of Ancestor more info
enables hemoglobin alpha binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	ISO Inferred from Sequence Orthology more info
contributes_to peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbon dioxide transport	NAS Non-traceable Author Statement more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxygen transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of haptoglobin-hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	ISO Inferred from Sequence Orthology more info
part_of hemoglobin complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: hemoglobin subunit epsilon-Y2

Names: epsilon Y globin; epsilon-Y2-globin; hemoglobin epsilon-Y2 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.