Guca2b guanylate cyclase activator 2b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Guca2bprovided by MGI
Official Full Name: guanylate cyclase activator 2bprovided by MGI
Primary source: MGI:MGI:1270851
See related: Ensembl:ENSMUSG00000032978 AllianceGenome:MGI:1270851
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ugn; Gcap2
Summary: This gene encodes a member of the guanylin family and preproprotein that is proteolytically processed to generate a mature protein product. The mature protein product, known as uroguanylin, is an endogenous ligand for the guanylate cyclase-C receptor and may regulate salt and water homeostasis in the intestine and kidneys. Homozygous knockout mice for this gene exhibit impaired sodium chloride excretion and elevated arterial pressure. This gene is present in a gene cluster with a related guanylin family member on chromosome 4. [provided by RefSeq, Sep 2015]
Expression: Biased expression in duodenum adult (RPKM 485.9), small intestine adult (RPKM 361.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 55.48 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (119513798..119516142, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (119656601..119658945, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes.
Title: Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.
guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage
Title: Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.
In obese mice UGN expression was decreased, whereas leptin treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT.
Title: Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner.
UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site.
Title: The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link.
Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading.
Title: The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response.
act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes.
Title: Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor.
existence of two signaling pathways for guanylin peptides in principal cells of mouse cortical collecting duct of kidney
Title: Uroguanylin and guanylin regulate transport of mouse cortical collecting duct independent of guanylate cyclase C.
findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo
Title: Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

AV066530 (e-PCR)
- UniSTS:165349

41.MMHAP25FLF5.seq (e-PCR)
- UniSTS:124403

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanylate cyclase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within body fluid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reduction of food intake in response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal sodium ion absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanylate cyclase activator 2B

Names: granule cell antiserum positive 2; guanylate cyclase activator 2b (retina); uroguanylin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.