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Gstt2 glutathione S-transferase, theta 2 [ Mus musculus (house mouse) ]

Gene ID: 14872, updated on 27-Nov-2024

Summary

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Official Symbol
Gstt2provided by MGI
Official Full Name
glutathione S-transferase, theta 2provided by MGI
Primary source
MGI:MGI:106188
See related
Ensembl:ENSMUSG00000033318 AllianceGenome:MGI:106188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Yrs; mGSTT2
Summary
Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)) and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 150.6), liver adult (RPKM 57.5) and 19 other tissues See more
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Genomic context

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See Gstt2 in Genome Data Viewer
Location:
10 C1; 10 38.58 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75667676..75673253, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75831842..75837419, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, theta 1 Neighboring gene glutathione S-transferase, theta 4 Neighboring gene STARR-positive B cell enhancer ABC_E9794 Neighboring gene STARR-positive B cell enhancer ABC_E5148 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:75300050-75300233 Neighboring gene predicted gene, 40697 Neighboring gene macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation. Kano SI, et al. Sci Signal, 2019 Feb 19. PMID 30783009, Free PMC Article
  2. Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. Whittington AT, et al. Genomics, 1996 Apr 1. PMID 8617493
  3. Mammalian class theta GST and differential susceptibility to carcinogens: a review. Landi S. Mutat Res, 2000 Oct. PMID 11018744
  4. Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1. Whittington A, et al. Biochem J, 1999 Jan 1. PMID 9854036, Free PMC Article
  5. Identification, characterization, and crystal structure of the Omega class glutathione transferases. Board PG, et al. J Biol Chem, 2000 Aug 11. PMID 10783391

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutathione S-transferase theta-2
Names
GST class-theta-2
NP_034491.2
XP_006513303.1
XP_006513304.1
XP_011241675.1
XP_030100749.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428510.1 → NP_001415439.1  glutathione S-transferase theta-2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC142499

  2. NM_001428511.1 → NP_001415440.1  glutathione S-transferase theta-2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4-7, encodes isoform c.
    Source sequence(s)
    AC142499

  3. NM_001428512.1 → NP_001415441.1  glutathione S-transferase theta-2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC142499

  4. NM_001428513.1 → NP_001415442.1  glutathione S-transferase theta-2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC142499

  5. NM_001428514.1 → NP_001415443.1  glutathione S-transferase theta-2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC142499

  6. NM_001428515.1 → NP_001415444.1  glutathione S-transferase theta-2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC142499

  7. NM_010361.3 → NP_034491.2  glutathione S-transferase theta-2 isoform b

    See identical proteins and their annotated locations for NP_034491.2

    Status: VALIDATED

    Source sequence(s)
    AC142499
    Consensus CDS
    CCDS48601.1
    UniProtKB/Swiss-Prot
    Q61133, Q61134, Q64472, Q91VB0
    Related
    ENSMUSP00000046324.7, ENSMUST00000038257.7
    Conserved Domains (2) summary
    cd03183
    Location:91 → 216
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cd03050
    Location:3 → 78
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75667676..75673253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513241.1 → XP_006513304.1  glutathione S-transferase theta-2 isoform X3

    Conserved Domains (1) summary
    cd03183
    Location:52 → 177
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

  2. XM_006513240.1 → XP_006513303.1  glutathione S-transferase theta-2 isoform X2

    See identical proteins and their annotated locations for XP_006513303.1

    UniProtKB/Swiss-Prot
    Q61133, Q61134, Q64472, Q91VB0
    Related
    ENSMUSP00000151239.2, ENSMUST00000220440.2
    Conserved Domains (2) summary
    cd03183
    Location:91 → 216
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cd03050
    Location:3 → 78
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

  3. XM_011243373.1 → XP_011241675.1  glutathione S-transferase theta-2 isoform X1

    Conserved Domains (2) summary
    cd03183
    Location:98 → 223
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cd03050
    Location:3 → 85
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

  4. XM_030244889.2 → XP_030100749.1  glutathione S-transferase theta-2 isoform X2

    UniProtKB/Swiss-Prot
    Q61133, Q61134, Q64472, Q91VB0
    Conserved Domains (2) summary
    cd03183
    Location:91 → 216
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cd03050
    Location:3 → 78
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61133.4 GenPept UniProtKB/Swiss-Prot:Q61133

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