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CIART circadian associated repressor of transcription [ Homo sapiens (human) ]

Gene ID: 148523, updated on 27-Nov-2024

Summary

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Official Symbol
CIARTprovided by HGNC
Official Full Name
circadian associated repressor of transcriptionprovided by HGNC
Primary source
HGNC:HGNC:25200
See related
Ensembl:ENSG00000159208 MIM:615782; AllianceGenome:HGNC:25200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GM129; CHRONO; C1orf51
Summary
Predicted to enable E-box binding activity. Predicted to be involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of DNA-templated transcription. Predicted to be located in PML body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart (RPKM 6.9), thyroid (RPKM 5.6) and 24 other tissues See more
Orthologs
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Genomic context

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See CIART in Genome Data Viewer
Location:
1q21.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150282554..150287093)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149407478..149412040)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150254964..150259505)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:150241516-150242127 Neighboring gene uncharacterized LOC124904414 Neighboring gene aph-1 homolog A, gamma-secretase subunit Neighboring gene chromosome 1 open reading frame 54 Neighboring gene Sharpr-MPRA regulatory region 3157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1679 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:150254031-150255230 Neighboring gene uncharacterized LOC105371434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150269465-150270023 Neighboring gene mitochondrial ribosomal protein S21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Tang X, et al. Nat Cell Biol, 2023 Mar. PMID 36918693, Free PMC Article
  2. CHRONO integrates behavioral stress and epigenetic control of metabolism. Hatanaka F, et al. Ann Med, 2017 Jun. PMID 28010116
  3. Machine learning helps identify CHRONO as a circadian clock component. Anafi RC, et al. PLoS Biol, 2014 Apr. PMID 24737000, Free PMC Article
  4. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. Annayev Y, et al. J Biol Chem, 2014 Feb 21. PMID 24385426, Free PMC Article
  5. A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. Goriki A, et al. PLoS Biol, 2014 Apr. PMID 24736997, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25889

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
circadian-associated transcriptional repressor
Names
chIP-derived repressor of network oscillator
computationally highlighted repressor of the network oscillator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300838.2 → NP_001287767.1  circadian-associated transcriptional repressor isoform a

    See identical proteins and their annotated locations for NP_001287767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC027999, CK904668
    Consensus CDS
    CCDS949.1
    UniProtKB/Swiss-Prot
    B2RD43, D3DV01, Q8N365, Q8N795, Q96MG6
    UniProtKB/TrEMBL
    Q8WVX4
    Related
    ENSP00000358091.1, ENST00000369095.5
    Conserved Domains (1) summary
    pfam15673
    Location:92 → 368
    Ciart; Circadian-associated transcriptional repressor

  2. NM_001300839.2 → NP_001287768.1  circadian-associated transcriptional repressor isoform b

    See identical proteins and their annotated locations for NP_001287768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
    Source sequence(s)
    BC017397, CK904668, EB388133
    Consensus CDS
    CCDS72906.1
    UniProtKB/TrEMBL
    Q5TB12, Q8WVX4
    Related
    ENSP00000358090.1, ENST00000369094.5
    Conserved Domains (1) summary
    pfam15673
    Location:4 → 280
    Ciart; Circadian-associated transcriptional repressor

  3. NM_001300840.2 → NP_001287769.1  circadian-associated transcriptional repressor isoform b

    See identical proteins and their annotated locations for NP_001287769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
    Source sequence(s)
    AK056960, CK904668, CN359562, EB388133
    Consensus CDS
    CCDS72906.1
    UniProtKB/TrEMBL
    Q5TB12, Q8WVX4
    Conserved Domains (1) summary
    pfam15673
    Location:4 → 280
    Ciart; Circadian-associated transcriptional repressor

  4. NM_001300841.2 → NP_001287770.1  circadian-associated transcriptional repressor isoform b

    See identical proteins and their annotated locations for NP_001287770.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (b).
    Source sequence(s)
    AC242988, AK056960, BE784098, CK904668, EB388133
    Consensus CDS
    CCDS72906.1
    UniProtKB/TrEMBL
    Q5TB12, Q8WVX4
    Related
    ENSP00000398291.1, ENST00000417398.5
    Conserved Domains (1) summary
    pfam15673
    Location:4 → 280
    Ciart; Circadian-associated transcriptional repressor

  5. NM_144697.4 → NP_653298.1  circadian-associated transcriptional repressor isoform a

    See identical proteins and their annotated locations for NP_653298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC242988, BC047238, CK904668, EB388133
    Consensus CDS
    CCDS949.1
    UniProtKB/Swiss-Prot
    B2RD43, D3DV01, Q8N365, Q8N795, Q96MG6
    UniProtKB/TrEMBL
    Q8WVX4
    Related
    ENSP00000290363.5, ENST00000290363.6
    Conserved Domains (1) summary
    pfam15673
    Location:92 → 368
    Ciart; Circadian-associated transcriptional repressor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    150282554..150287093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446893.1 → XP_047302849.1  circadian-associated transcriptional repressor isoform X1

    UniProtKB/Swiss-Prot
    B2RD43, D3DV01, Q8N365, Q8N795, Q96MG6

  2. XM_024453375.2 → XP_024309143.1  circadian-associated transcriptional repressor isoform X2

    UniProtKB/TrEMBL
    Q5TB12, Q8WVX4
    Conserved Domains (1) summary
    pfam15673
    Location:4 → 280
    Ciart; Circadian-associated transcriptional repressor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    149407478..149412040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334575.1 → XP_054190550.1  circadian-associated transcriptional repressor isoform X1

    UniProtKB/Swiss-Prot
    B2RD43, D3DV01, Q8N365, Q8N795, Q96MG6

  2. XM_054334576.1 → XP_054190551.1  circadian-associated transcriptional repressor isoform X2

    UniProtKB/TrEMBL
    Q5TB12
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N365.1 GenPept UniProtKB/Swiss-Prot:Q8N365

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