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Grb7 growth factor receptor bound protein 7 [ Mus musculus (house mouse) ]

Gene ID: 14786, updated on 27-Nov-2024

Summary

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Official Symbol
Grb7provided by MGI
Official Full Name
growth factor receptor bound protein 7provided by MGI
Primary source
MGI:MGI:102683
See related
Ensembl:ENSMUSG00000019312 AllianceGenome:MGI:102683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4028
Summary
Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein kinase binding activity. Involved in negative regulation of translation and stress granule assembly. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in esophagus adenocarcinoma. Orthologous to human GRB7 (growth factor receptor bound protein 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 50.8), liver adult (RPKM 48.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Grb7 in Genome Data Viewer
Location:
11 D; 11 61.75 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98337660..98346199)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98446834..98455373)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98254740-98254849 Neighboring gene STARR-seq mESC enhancer starr_30667 Neighboring gene post-GPI attachment to proteins 3 Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5275 Neighboring gene migration and invasion enhancer 1 Neighboring gene STARR-seq mESC enhancer starr_30668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320467-98320833 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320999-98321108 Neighboring gene STARR-positive B cell enhancer ABC_E11772 Neighboring gene IKAROS family zinc finger 3 Neighboring gene predicted gene, 25106 Neighboring gene STARR-positive B cell enhancer ABC_E7058 Neighboring gene VISTA enhancer mm503 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98388491-98388674 Neighboring gene STARR-positive B cell enhancer ABC_E8880 Neighboring gene STARR-positive B cell enhancer ABC_E8450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98412942-98413125 Neighboring gene zona pellucida binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females. Vermehren-Schmaedick A, et al. Endocrinology, 2024 Mar 29. PMID 38578949, Free PMC Article
  2. Grb7 knockout mice develop normally but litters born to knockout females fail to thrive. Lofgren KA, et al. Dev Dyn, 2024 Jul. PMID 38140940
  3. The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. Tsai NP, et al. EMBO J, 2007 Mar 21. PMID 17318180, Free PMC Article
  4. Expression of Grb7 growth factor receptor signaling protein in kidney development and in adult kidney. Leavey SF, et al. Am J Physiol, 1998 Nov. PMID 9815134
  5. Mmu-miR-193 is involved in embryo implantation in mouse uterus by regulating GRB7 gene expression. Li R, et al. Reprod Sci, 2014 Jun. PMID 24336674, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females.
    Title: Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females.
  2. GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR-193.
    Title: Mmu-miR-193 is involved in embryo implantation in mouse uterus by regulating GRB7 gene expression.
  3. Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
    Title: EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.
  4. Grb7 is identified as an integral component of stress granules.
    Title: Regulation of stress granule dynamics by Grb7 and FAK signalling pathway.
  5. The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation of kappa opioid receptor.
    Title: The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4028, MGC78181

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
growth factor receptor-bound protein 7
Names
GRB7 adapter protein
Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7)
epidermal growth factor receptor GRB-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010346.2 → NP_034476.1  growth factor receptor-bound protein 7

    See identical proteins and their annotated locations for NP_034476.1

    Status: VALIDATED

    Source sequence(s)
    AK168438, AW494536, CA496861
    Consensus CDS
    CCDS25351.1
    UniProtKB/Swiss-Prot
    Q03160, Q3TH55
    Related
    ENSMUSP00000019456.5, ENSMUST00000019456.5
    Conserved Domains (4) summary
    cd10413
    Location:428 → 535
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:224 → 350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16140
    Location:102 → 186
    RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
    pfam08947
    Location:369 → 413
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98337660..98346199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532233.1 → XP_006532296.1  growth factor receptor-bound protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006532296.1

    UniProtKB/Swiss-Prot
    Q03160, Q3TH55
    Conserved Domains (4) summary
    cd10413
    Location:428 → 535
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:224 → 350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16140
    Location:102 → 186
    RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
    pfam08947
    Location:369 → 413
    BPS; BPS (Between PH and SH2)

  2. XM_030245575.1 → XP_030101435.1  growth factor receptor-bound protein 7 isoform X1

    UniProtKB/Swiss-Prot
    Q03160, Q3TH55
    Conserved Domains (4) summary
    cd10413
    Location:428 → 535
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:224 → 350
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16140
    Location:102 → 186
    RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
    pfam08947
    Location:369 → 413
    BPS; BPS (Between PH and SH2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03160.1 GenPept UniProtKB/Swiss-Prot:Q03160

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