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Gpr12 G-protein coupled receptor 12 [ Mus musculus (house mouse) ]

Gene ID: 14738, updated on 27-Nov-2024

Summary

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Official Symbol
Gpr12provided by MGI
Official Full Name
G-protein coupled receptor 12provided by MGI
Primary source
MGI:MGI:101909
See related
Ensembl:ENSMUSG00000041468 AllianceGenome:MGI:101909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpcr01; Gpcr12; Gpcr20; Gpcr21
Summary
Enables phosphatidylcholine binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway and intracellular calcium ion homeostasis. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; gut; and liver. Used to study obesity. Orthologous to human GPR12 (G protein-coupled receptor 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 6.4), cortex adult (RPKM 4.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr12 in Genome Data Viewer
Location:
5 G3; 5 85.23 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146518960..146523274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146582150..146586465, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3415 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14847 Neighboring gene predicted gene, 34333 Neighboring gene STARR-seq mESC enhancer starr_14848 Neighboring gene STARR-positive B cell enhancer ABC_E11731 Neighboring gene STARR-positive B cell enhancer ABC_E2772 Neighboring gene STARR-positive B cell enhancer ABC_E6399 Neighboring gene STARR-positive B cell enhancer ABC_E6400 Neighboring gene predicted gene, 34700

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice. Frank E, et al. PLoS One, 2012. PMID 22879962, Free PMC Article
  2. A Thalamic Orphan Receptor Drives Variability in Short-Term Memory. Hsiao K, et al. Cell, 2020 Oct 15. PMID 32997977, Free PMC Article
  3. G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. Bjursell M, et al. Biochem Biophys Res Commun, 2006 Sep 22. PMID 16887097
  4. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. Ignatov A, et al. J Neurosci, 2003 Feb 1. PMID 12574419, Free PMC Article
  5. Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth. Tanaka S, et al. J Biol Chem, 2007 Apr 6. PMID 17284443

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Thalamic Orphan Receptor Drives Variability in Short-Term Memory.
    Title: A Thalamic Orphan Receptor Drives Variability in Short-Term Memory.
  2. Studying metabolic and emotionality parameters in Gpr12 mutant mice did not reveal a major phenotypic impact of the gene mutation.
    Title: Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice.
  3. the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12
    Title: The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes.
  4. GPCR12 is considered important for the energy balance since GPCR12 KO mice develop obesity and have lower energy expenditure.
    Title: G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010941.2 → NP_001010941.1  G-protein coupled receptor 12 isoform a

    See identical proteins and their annotated locations for NP_001010941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AK140298, AW125657, BB653482, BC055746
    Consensus CDS
    CCDS19871.1
    UniProtKB/Swiss-Prot
    P35412
    Related
    ENSMUSP00000038245.7, ENSMUST00000036211.8
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001359055.1 → NP_001345984.1  G-protein coupled receptor 12 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AC127589
    Consensus CDS
    CCDS19871.1
    UniProtKB/Swiss-Prot
    P35412
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001359056.1 → NP_001345985.1  G-protein coupled receptor 12 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AC127589
    Consensus CDS
    CCDS19871.1
    UniProtKB/Swiss-Prot
    P35412
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001359057.1 → NP_001345986.1  G-protein coupled receptor 12 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AC127589
    Consensus CDS
    CCDS19871.1
    UniProtKB/Swiss-Prot
    P35412
    Related
    ENSMUSP00000142889.2, ENSMUST00000197431.2
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_001359058.1 → NP_001345987.1  G-protein coupled receptor 12 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC127589, BY779961
    Conserved Domains (2) summary
    cd14964
    Location:1 → 16
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 153
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. NM_008151.3 → NP_032177.1  G-protein coupled receptor 12 isoform a

    See identical proteins and their annotated locations for NP_032177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the 5' exon but has an alternate 5' segment, as compared to variant 3. Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AW125657, BC055746
    Consensus CDS
    CCDS19871.1
    UniProtKB/Swiss-Prot
    P35412
    Related
    ENSMUST00000196096.2
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146518960..146523274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254133.2 → XP_030109993.1  G-protein coupled receptor 12 isoform X1

    UniProtKB/Swiss-Prot
    P35412
    Conserved Domains (1) summary
    cd15961
    Location:45 → 312
    7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_030254134.2 → XP_030109994.1  G-protein coupled receptor 12 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:1 → 16
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 153
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35412.1 GenPept UniProtKB/Swiss-Prot:P35412

Gene LinkOut

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