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KIF18B kinesin family member 18B [ Homo sapiens (human) ]

Gene ID: 146909, updated on 27-Nov-2024

Summary

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Official Symbol
KIF18Bprovided by HGNC
Official Full Name
kinesin family member 18Bprovided by HGNC
Primary source
HGNC:HGNC:27102
See related
Ensembl:ENSG00000186185 MIM:614570; AllianceGenome:HGNC:27102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables cytoskeletal motor activity and kinesin binding activity. Involved in microtubule depolymerization; mitotic cell cycle; and regulation of cell division. Located in cytosol; microtubule; and nuclear body. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bone marrow (RPKM 3.6), lymph node (RPKM 2.4) and 14 other tissues See more
Orthologs
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Genomic context

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See KIF18B in Genome Data Viewer
Location:
17q21.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44924711..44947773, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45778623..45801668, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43002079..43025141, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene RNA, 7SL, cytoplasmic 405, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:42969539-42970081 Neighboring gene dynein axonemal assembly factor 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8603 Neighboring gene family with sequence similarity 187 member A Neighboring gene glial fibrillary acidic protein Neighboring gene uncharacterized LOC105371793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42997401-42997900 Neighboring gene microRNA 6783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43025111-43025630 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43031038-43031303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43039086-43039586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8604 Neighboring gene basic proline-rich protein-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8605 Neighboring gene complement C1q like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential Expression of KIF18B in Gastric Cancer and Its Role in Chemotherapy Sensitivity. Gan LH, et al. Crit Rev Eukaryot Gene Expr, 2024. PMID 38305287
  2. Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8. Shin Y, et al. Proc Natl Acad Sci U S A, 2015 Jul 21. PMID 26150501, Free PMC Article
  3. Kinesin family member 18B: A contributor and facilitator in the proliferation and metastasis of cutaneous melanoma. Yan H, et al. J Biochem Mol Toxicol, 2019 Dec. PMID 31617652
  4. KIF18B as a regulator in microtubule movement accelerates tumor progression and triggers poor outcome in lung adenocarcinoma. Ji Z, et al. Tissue Cell, 2019 Dec. PMID 31759406
  5. Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma. Liu W, et al. EBioMedicine, 2020 Nov. PMID 33038765, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition.
    Title: Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition.
  2. Differential Expression of KIF18B in Gastric Cancer and Its Role in Chemotherapy Sensitivity.
    Title: Differential Expression of KIF18B in Gastric Cancer and Its Role in Chemotherapy Sensitivity.
  3. Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway.
    Title: Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway.
  4. miR-139-3p/Kinesin family member 18B axis suppresses malignant progression of gastric cancer.
    Title: miR-139-3p/Kinesin family member 18B axis suppresses malignant progression of gastric cancer.
  5. Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3beta/beta-catenin pathway.
    Title: Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3β/β-catenin pathway.
  6. The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair.
    Title: The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair.
  7. KIF18b-dependent hypomethylation of PARPBP gene promoter enhances oxaliplatin resistance in colorectal cancer.
    Title: KIF18b-dependent hypomethylation of PARPBP gene promoter enhances oxaliplatin resistance in colorectal cancer.
  8. Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
    Title: Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
  9. KIF18B promotes tumor progression in osteosarcoma by activating beta-catenin.
    Title: KIF18B promotes tumor progression in osteosarcoma by activating β-catenin.
  10. KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma.
    Title: KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule end IDA
Inferred from Direct Assay
more info
  
located_in microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF18B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001264573.2 → NP_001251503.1  kinesin-like protein KIF18B isoform 2

    See identical proteins and their annotated locations for NP_001251503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015936, BC067365, BC144271, BX405609
    Consensus CDS
    CCDS58555.1
    UniProtKB/TrEMBL
    A0A494BYR6
    Related
    ENSP00000465377.1, ENST00000587309.5
    Conserved Domains (2) summary
    smart00129
    Location:9 → 358
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:7 → 351
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

  2. NM_001265577.2 → NP_001252506.1  kinesin-like protein KIF18B isoform 1

    See identical proteins and their annotated locations for NP_001252506.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC015936, BC067365, BC136590, BX405609
    Consensus CDS
    CCDS45709.2
    UniProtKB/Swiss-Prot
    A0A0C4DGP2, A0A0C4DGP5, A6NJI2, B7ZM49, B9EGM8, D5L6I1, Q86Y91
    UniProtKB/TrEMBL
    A0A494BYR6
    Related
    ENSP00000465992.1, ENST00000593135.6
    Conserved Domains (2) summary
    PHA03247
    Location:585 → 824
    PHA03247; large tegument protein UL36; Provisional
    cd01370
    Location:7 → 351
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    44924711..44947773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524386.3 → XP_011522688.1  kinesin-like protein KIF18B isoform X3

    UniProtKB/TrEMBL
    A0A494BYR6
    Conserved Domains (2) summary
    smart00129
    Location:9 → 358
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:7 → 351
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

  2. XM_047435469.1 → XP_047291425.1  kinesin-like protein KIF18B isoform X7

  3. XM_011524387.3 → XP_011522689.1  kinesin-like protein KIF18B isoform X2

    UniProtKB/TrEMBL
    A0A494BYR6
    Conserved Domains (2) summary
    smart00129
    Location:18 → 367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16 → 360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

  4. XM_011524385.3 → XP_011522687.1  kinesin-like protein KIF18B isoform X1

    UniProtKB/TrEMBL
    A0A494BYR6
    Conserved Domains (2) summary
    smart00129
    Location:18 → 367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16 → 360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

  5. XM_011524389.3 → XP_011522691.1  kinesin-like protein KIF18B isoform X5

    UniProtKB/TrEMBL
    A0A494BYR6
    Conserved Domains (2) summary
    smart00129
    Location:18 → 367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16 → 360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

  6. XM_011524390.2 → XP_011522692.1  kinesin-like protein KIF18B isoform X6

    UniProtKB/TrEMBL
    A0A494BYR6
    Conserved Domains (2) summary
    smart00129
    Location:18 → 332
    KISc; Kinesin motor, catalytic domain. ATPase
    cl22853
    Location:16 → 325
    Motor_domain; Myosin and Kinesin motor domain

  7. XM_011524388.3 → XP_011522690.1  kinesin-like protein KIF18B isoform X4

    UniProtKB/TrEMBL
    A0A494BYR6
    Conserved Domains (2) summary
    smart00129
    Location:18 → 367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16 → 360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

  8. XM_011524391.4 → XP_011522693.1  kinesin-like protein KIF18B isoform X8

    Conserved Domains (2) summary
    smart00129
    Location:18 → 367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16 → 360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    45778623..45801668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315216.1 → XP_054171191.1  kinesin-like protein KIF18B isoform X3

  2. XM_054315215.1 → XP_054171190.1  kinesin-like protein KIF18B isoform X2

  3. XM_054315218.1 → XP_054171193.1  kinesin-like protein KIF18B isoform X5

  4. XM_054315214.1 → XP_054171189.1  kinesin-like protein KIF18B isoform X1

  5. XM_054315220.1 → XP_054171195.1  kinesin-like protein KIF18B isoform X7

  6. XM_054315219.1 → XP_054171194.1  kinesin-like protein KIF18B isoform X6

  7. XM_054315217.1 → XP_054171192.1  kinesin-like protein KIF18B isoform X4

  8. XM_054315221.1 → XP_054171196.1  kinesin-like protein KIF18B isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080443.1: Suppressed sequence

    Description
    NM_001080443.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86Y91.4 GenPept UniProtKB/Swiss-Prot:Q86Y91

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