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ghoT toxin of the GhoTS toxin-antitoxin system [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 1450308, updated on 3-Dec-2024

Summary

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Official Symbol
ghoT
Official Full Name
toxin of the GhoTS toxin-antitoxin system
Primary source
ECOCYC:G0-10472
Locus tag
b4559
See related
ASAP:ABE-0285080
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4122; yjdO
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Genomic context

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Sequence:
NC_000913.3 (4352908..4353081)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative N-acetyltransferase YjdJ Neighboring gene antitoxin of the GhoTS toxin-antitoxin system Neighboring gene lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase Neighboring gene dipeptide/tripeptide:H(+) symporter DtpC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress. Cheng HY, et al. Environ Microbiol, 2014 Jun. PMID 24373067
  2. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
  3. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503
  4. Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Riley M, et al. Nucleic Acids Res, 2006. PMID 16397293, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GhoT reduces metabolism by reducing ATP and proton motive force and that this reduction in metabolism is important for growth with various antimicrobials.
    Title: Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Component Evidence Code Pubs
located_in cell pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
toxin of the GhoTS toxin-antitoxin system

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4352908..4353081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_588474.1 toxin of the GhoTS toxin-antitoxin system [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_588474.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P64646
    Conserved Domains (1) summary
    pfam10753
    Location:4 → 57
    Toxin_GhoT_OrtT; Toxin GhoT_OrtT
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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