U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Folr1 folate receptor alpha [ Mus musculus (house mouse) ]

Gene ID: 14275, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Folr1provided by MGI
Official Full Name
folate receptor alphaprovided by MGI
Primary source
MGI:MGI:95568
See related
Ensembl:ENSMUSG00000001827 AllianceGenome:MGI:95568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP1; Folbp1; Folbp-1
Summary
Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Involved in circulatory system development; nervous system development; and regulation of signal transduction. Acts upstream of or within folic acid metabolic process. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 188.9), placenta adult (RPKM 82.7) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Folr1 in Genome Data Viewer
Location:
7 E2; 7 54.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101507551..101519974, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101858331..101870788, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene predicted gene 10602 Neighboring gene folate receptor beta Neighboring gene STARR-seq mESC enhancer starr_19700 Neighboring gene predicted gene, 35597 Neighboring gene anaphase promoting complex C subunit 15 Neighboring gene STARR-positive B cell enhancer ABC_E2837 Neighboring gene STARR-positive B cell enhancer ABC_E1350 Neighboring gene transmembrane O-methyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation. Finnell RH, et al. J Nutr, 2002 Aug. PMID 12163711
  2. MHC class II epitope nesting modulates dendritic cell function and improves generation of antigen-specific CD4 helper T cells. Erskine CL, et al. J Immunol, 2011 Jul 1. PMID 21613617, Free PMC Article
  3. Folbp1 promotes embryonic myocardial cell proliferation and apoptosis through the WNT signal transduction pathway. Han SP, et al. Int J Mol Med, 2009 Mar. PMID 19212649
  4. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Xia W, et al. Blood, 2009 Jan 8. PMID 18952896
  5. Folate receptor expression in pituitary adenomas cellular and molecular analysis. Evans CO, et al. Vitam Horm, 2008. PMID 18804697

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of folate receptor alpha in the partial rejuvenation of dentate gyrus cells: Improvement of cognitive function in 21-month-old aged mice.
    Title: Role of folate receptor α in the partial rejuvenation of dentate gyrus cells: Improvement of cognitive function in 21-month-old aged mice.
  2. Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys.
    Title: Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys.
  3. Gestational folate deficiency alters embryonic gene expression and cell function.
    Title: Gestational folate deficiency alters embryonic gene expression and cell function.
  4. Several experimental studies in mice and human epidemiological and genetics studies have suggested that FOLR1 abnormalities are involved in a portion of human neural tube defects (NTD), although the solo defect of FOLR1 did not cause NTD. (Review)
    Title: Folate receptors and neural tube closure.
  5. Midbrain dopamine neural progenitors and nascent dopamine neurons specifically express Folr1.
    Title: FolR1: a novel cell surface marker for isolating midbrain dopamine neural progenitors and nascent dopamine neurons.
  6. The above showed that human FRalpha based DNA vaccination with CpG oligodeoxynucleotides as an adjuvant was effective in growth inhibition of a FRalpha expressing tumor in mice and deserves further evaluation as a possible immunotherapy
    Title: CpG oligodeoxynucleotides augment antitumor efficacy of folate receptor α based DNA vaccine.
  7. Folate receptor alpha upregulates Oct4, Sox2 and Klf4 and downregulates miR-138 and miR-let-7 in cranial neural crest cells.
    Title: Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells.
  8. not detected in oocytes
    Title: Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size.
  9. Folate receptor expression on murine and human adipose tissue macrophages
    Title: Folate receptor expression on murine and human adipose tissue macrophages.
  10. Quantitative RT-PCR showed that Slc19a1 mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed expression only in preimplantation embryos, increasing from the 2-cell stage onward.
    Title: Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables folic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables folic acid binding TAS
Traceable Author Statement
more info
 PubMed 
enables folic acid receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables folic acid receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables folic acid receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to folic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to folic acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within folic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in folic acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in folic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural crest cell migration involved in heart formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm-egg recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
folate receptor alpha
Names
FR-alpha
folate receptor 1 (adult)
folate-binding protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252552.2 → NP_001239481.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All 16 variants encode the same protein.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Related
    ENSMUSP00000102598.2, ENSMUST00000106985.8
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  2. NM_001252553.2 → NP_001239482.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239482.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two different splice sites in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  3. NM_001252554.2 → NP_001239483.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Related
    ENSMUSP00000102596.2, ENSMUST00000106983.8
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  4. NM_001412428.1 → NP_001399357.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  5. NM_001412429.1 → NP_001399358.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  6. NM_001412430.1 → NP_001399359.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  7. NM_001412431.1 → NP_001399360.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  8. NM_001412432.1 → NP_001399361.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  9. NM_001412433.1 → NP_001399362.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  10. NM_001412434.1 → NP_001399363.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  11. NM_001412435.1 → NP_001399364.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  12. NM_001412436.1 → NP_001399365.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    Related
    ENSMUSP00000102595.2, ENSMUST00000106982.8

  13. NM_001412437.1 → NP_001399366.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  14. NM_001412438.1 → NP_001399367.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222

  15. NM_001412439.1 → NP_001399368.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    Related
    ENSMUSP00000102594.2, ENSMUST00000106981.8

  16. NM_008034.4 → NP_032060.2  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_032060.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Related
    ENSMUSP00000102599.3, ENSMUST00000106986.9
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101507551..101519974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507369.3 → XP_006507432.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507432.1

    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  2. XM_006507366.4 → XP_006507429.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507429.1

    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  3. XM_006507364.4 → XP_006507427.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507427.1

    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family

  4. XM_006507367.5 → XP_006507430.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507430.1

    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34 → 209
    Folate_rec; Folate receptor family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35846.2 GenPept UniProtKB/Swiss-Prot:P35846

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous