Cdk5 cyclin-dependent kinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140908, updated on 27-Nov-2024

Summary

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Official Symbol: Cdk5provided by RGD
Official Full Name: cyclin-dependent kinase 5provided by RGD
Primary source: RGD:70514
See related: EnsemblRapid:ENSRNOG00000008017 AllianceGenome:RGD:70514
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including ephrin receptor binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Acts upstream of or within protein phosphorylation. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Used to study brain ischemia; depressive disorder; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 242.9), Adrenal (RPKM 102.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Cdk5 in Genome Data Viewer

Location:: 4q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (11647098..11651606)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (10754682..10760110)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (7282945..7287427)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdk5 mediates rotational force-induced brain injury.
Title: Cdk5 mediates rotational force-induced brain injury.
CDK5 Mediates Proinflammatory Effects of Microglia through Activated DRP1 Phosphorylation in Rat Model of Intracerebral Hemorrhage.
Title: CDK5 Mediates Proinflammatory Effects of Microglia through Activated DRP1 Phosphorylation in Rat Model of Intracerebral Hemorrhage.
Diabetes-Induced H3K9 Hyperacetylation Promotes Development of Alzheimer's Disease Through CDK5.
Title: Diabetes-Induced H3K9 Hyperacetylation Promotes Development of Alzheimer's Disease Through CDK5.
MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5/FOXC2 pathway.
Title: MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5/FOXC2 pathway.
CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP().
Title: CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP().
Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury.
Title: Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury.
Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy.
Title: Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy.
CDK5 Participates in Amyloid-beta Production by Regulating PPARgamma Phosphorylation in Primary Rat Hippocampal Neurons.
Title: CDK5 Participates in Amyloid-β Production by Regulating PPARγ Phosphorylation in Primary Rat Hippocampal Neurons.
Cdk5 phosphorylates CaV1.3 channels and regulates GABAA-mediated miniature inhibitory post-synaptic currents in striato-nigral terminals.
Title: Cdk5 phosphorylates Ca(V)1.3 channels and regulates GABA(A)-mediated miniature inhibitory post-synaptic currents in striato-nigral terminals.
Epigenetic Control of CDK5 Promoter Regulates Diabetes-Associated Development of Alzheimer's Disease.
Title: Epigenetic Control of CDK5 Promoter Regulates Diabetes-Associated Development of Alzheimer's Disease.

Submit: New GeneRIF Correction See all GeneRIFs (135)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC30213P2 (e-PCR)
- UniSTS:272488

Cdk5 (e-PCR), detects polymorphism
- UniSTS:531446

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ErbB-2 class receptor binding	IEA Inferred from Electronic Annotation more info
enables ErbB-2 class receptor binding	ISO Inferred from Sequence Orthology more info
enables ErbB-2 class receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables ErbB-3 class receptor binding	IEA Inferred from Electronic Annotation more info
enables ErbB-3 class receptor binding	ISO Inferred from Sequence Orthology more info
enables ErbB-3 class receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables acetylcholine receptor activator activity	IEA Inferred from Electronic Annotation more info
enables acetylcholine receptor activator activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Schwann cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Schwann cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
involved_in axon extension	TAS Traceable Author Statement more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to cocaine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system neuron development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar cortex development	ISO Inferred from Sequence Orthology more info
involved_in cerebellar cortex formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellar cortex formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within corpus callosum development	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in layer formation in cerebral cortex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of presynaptic cytosolic calcium concentration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to synapse	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to synapse	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in receptor catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse pruning	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synapse pruning	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	TAS Traceable Author Statement more info	PubMed
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	TAS Traceable Author Statement more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein kinase 5 complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein kinase 5 complex	IEA Inferred from Electronic Annotation more info
part_of protein kinase 5 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase 5

Names: TPKII catalytic subunit; cell division protein kinase 5; cyclin-dependent-like kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit

NP_543161.1

EC 2.7.11.1

XP_063141514.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080885.2 → NP_543161.1 cyclin-dependent kinase 5

See identical proteins and their annotated locations for NP_543161.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q03114

UniProtKB/TrEMBL

A0A8L2UIH0, A6K556

Related

ENSRNOP00000011052.3, ENSRNOT00000011052.6

Conserved Domains (1) summary

cd07839
Location:3 → 286

STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5