nanos3 nanos homolog 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nanos3provided by ZNC
Official Full Name: nanos homolog 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-011221-1
See related: Ensembl:ENSDARG00000068255 AllianceGenome:ZFIN:ZDB-GENE-011221-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nos1; cb725; nanos; nanos1
Summary: Enables identical protein binding activity and single-stranded RNA binding activity. Involved in germ cell development; germ cell migration; and negative regulation of protein phosphorylation. Acts upstream of or within female germ-line stem cell population maintenance and oocyte growth. Located in P granule. Is expressed in blastodisc; forebrain; germ line cell; reproductive system; and unfertilized egg. Orthologous to human NANOS3 (nanos C2HC-type zinc finger 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (55247374..55248496, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (54569723..54570845, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that nanos3 function is required for the maintenance of germline stem cell (GSC), but not for their specification, and suggest that nanos2 and nanos3 are partially redundant in this role.
Title: nanos3 maintains germline stem cells and expression of the conserved germline stem cell gene nanos2 in the zebrafish ovary.
Data show a novel interaction between zebrafish Nanos and myosin light chain II (Mylz2).
Title: Zebrafish Nanos interacts with and regulates the phosphorylation of Mylz2.
These results provide the structural basis for further studies to clarify Nanos function.
Title: Crystal structure of zinc-finger domain of Nanos and its functional implications.
Preliminary x ray diffraction studies the C-terminal domain (residues 59-159) of zebrafish Nanos, is reported.
Title: Purification, crystallization and initial X-ray diffraction study of the zinc-finger domain of zebrafish Nanos.
Regulatory interplay between Nos and Pumilio (Pum) could cause a small change in Pum activity to be amplified into a large shift in the balance between GluRIIA and GluRIIB subunit synapses.
Title: The translational repressors Nanos and Pumilio have divergent effects on presynaptic terminal growth and postsynaptic glutamate receptor subunit composition.
Using transgenes that compromise nos mRNA localization and translational regulation, we show that wild-type body patterning can ensue without nos mRNA localization provided that nos translation is properly modulated
Title: Dispensability of nanos mRNA localization for abdominal patterning but not for germ cell development.
In zebrafish nanos is expressed in early stage oocytes in the adult female germline.
Title: nanos1 is required to maintain oocyte production in adult zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oocyte growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nanos homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.