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gucy2f guanylate cyclase 2F, retinal [ Danio rerio (zebrafish) ]

Gene ID: 140424, updated on 5-Jan-2025

Summary

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Official Symbol
gucy2fprovided by ZNC
Official Full Name
guanylate cyclase 2F, retinalprovided by ZNC
Primary source
ZFIN:ZDB-GENE-011128-7
See related
Ensembl:ENSDARG00000025504 AllianceGenome:ZFIN:ZDB-GENE-011128-7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gc1; RETGC-1
Summary
Enables guanylate cyclase activity. Acts upstream of or within photoreceptor cell outer segment organization and visual perception. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in olfactory epithelium; olfactory receptor cell; retina; and retinal outer nuclear layer. Used to study Leber congenital amaurosis. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See gucy2f in Genome Data Viewer
Location:
chromosome: 15
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (29359745..29382011)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (29426865..29451008)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein 2a Neighboring gene si:dkey-52l18.4 Neighboring gene tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) Neighboring gene serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis. Stiebel-Kalish H, et al. Eur J Hum Genet, 2012 Aug. PMID 22378290, Free PMC Article
  2. NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation. Cudia DL, et al. Biochemistry, 2024 May 21. PMID 38662574
  3. Early-Life Benzo[a]Pyrene Exposure Causes Neurodegenerative Syndromes in Adult Zebrafish (Danio rerio) and the Mechanism Involved. Gao D, et al. Toxicol Sci, 2017 May 1. PMID 28329817
  4. Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Rätscho N, et al. Biochim Biophys Acta, 2009 Jun. PMID 19168097
  5. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. Brockerhoff SE, et al. J Neurosci, 2003 Jan 15. PMID 12533607, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gucy2f knockdown resulted in significantly lower vision.
    Title: Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within photoreceptor cell outer segment organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
retinal guanylyl cyclase 2
Names
guanylyl cyclase 1
NP_571939.2
XP_009289889.1
XP_017214686.1
XP_021337004.1
XP_068069554.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131864.2 → NP_571939.2  retinal guanylyl cyclase 2

    See identical proteins and their annotated locations for NP_571939.2

    Status: PROVISIONAL

    Source sequence(s)
    BX537138
    UniProtKB/TrEMBL
    B3DHF2, B3DHH4
    Related
    ENSDARP00000109090.2, ENSDART00000126196.4
    Conserved Domains (4) summary
    cd06371
    Location:59 → 440
    PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    smart00044
    Location:850 → 1042
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:551 → 816
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam07701
    Location:825 → 870
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    29359745..29382011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017359197.3 → XP_017214686.1  retinal guanylyl cyclase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z295, F1QWF7
    Related
    ENSDARP00000090689.4, ENSDART00000099916.5
    Conserved Domains (7) summary
    cd06371
    Location:59 → 440
    PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    smart00044
    Location:850 → 1042
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:551 → 816
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam00211
    Location:876 → 1063
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:76 → 416
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:825 → 870
    HNOBA; Heme NO binding associated
    pfam07714
    Location:569 → 806
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_021481329.2 → XP_021337004.1  retinal guanylyl cyclase 2 isoform X1

    UniProtKB/TrEMBL
    B3DHF2, B3DHH4
    Conserved Domains (4) summary
    cd06371
    Location:59 → 440
    PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    smart00044
    Location:850 → 1042
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:551 → 816
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam07701
    Location:825 → 870
    HNOBA; Heme NO binding associated

  3. XM_068213453.1 → XP_068069554.1  retinal guanylyl cyclase 2 isoform X1

    UniProtKB/TrEMBL
    B3DHF2, B3DHH4

  4. XM_009291614.4 → XP_009289889.1  retinal guanylyl cyclase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M3APR2
    Conserved Domains (7) summary
    cd06371
    Location:59 → 440
    PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    smart00044
    Location:850 → 1042
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:551 → 816
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam00211
    Location:876 → 1063
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:76 → 416
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:825 → 870
    HNOBA; Heme NO binding associated
    pfam07714
    Location:569 → 806
    Pkinase_Tyr; Protein tyrosine kinase

RNA

  1. XR_011006330.1 RNA Sequence

  2. XR_011006331.1 RNA Sequence

  3. XR_011006329.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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