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Ces3b carboxylesterase 3B [ Mus musculus (house mouse) ]

Gene ID: 13909, updated on 27-Nov-2024

Summary

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Official Symbol
Ces3bprovided by MGI
Official Full Name
carboxylesterase 3Bprovided by MGI
Primary source
MGI:MGI:3644960
See related
Ensembl:ENSMUSG00000062181 AllianceGenome:MGI:3644960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Es31; Ces3L; ES31L; Ces31L; Gm4738; EG13909
Summary
Predicted to enable carboxylesterase activity. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver adult (RPKM 134.0) See more
Orthologs
human all
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Genomic context

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See Ces3b in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105810365..105820561)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105083733..105093929)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2H Neighboring gene STARR-seq mESC enhancer starr_22519 Neighboring gene carboxylesterase 3A Neighboring gene STARR-positive B cell enhancer ABC_E5035 Neighboring gene microtubule-associated protein, RP/EB family, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22521 Neighboring gene carboxylesterase 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver. Aida K, et al. Biochim Biophys Acta, 1993 Jul 18. PMID 7916639
  2. Mammalian carboxylesterase 3: comparative genomics and proteomics. Holmes RS, et al. Genetica, 2010 Jul. PMID 20422440, Free PMC Article
  3. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxylesterase 3B
NP_001152887.1
NP_653094.2
XP_006530716.1
XP_006530717.1
XP_006530718.1
XP_006530719.1
XP_006530720.1
XP_006530721.1
XP_017168050.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159415.1 → NP_001152887.1  carboxylesterase 3B isoform 2 precursor

    See identical proteins and their annotated locations for NP_001152887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC164311, AI048193, AI173514, CA455872, CB946634, CB947075
    Consensus CDS
    CCDS52653.1
    UniProtKB/Swiss-Prot
    Q8VCU1
    Related
    ENSMUSP00000074004.7, ENSMUST00000074403.13
    Conserved Domains (2) summary
    COG0657
    Location:75 → 245
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:36 → 497
    COesterase; Carboxylesterase family

  2. NM_144511.2 → NP_653094.2  carboxylesterase 3B isoform 1 precursor

    See identical proteins and their annotated locations for NP_653094.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC164311, AI048193, AI173514, CA455872, CB946634, CB947075
    Consensus CDS
    CCDS22590.2
    UniProtKB/Swiss-Prot
    G5E8G7, G5E8K9, Q8VCU1, Q91XD5
    Related
    ENSMUSP00000090909.7, ENSMUST00000093221.13
    Conserved Domains (2) summary
    COG0657
    Location:75 → 245
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:36 → 547
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105810365..105820561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530654.4 → XP_006530717.1  carboxylesterase 3B isoform X2

    Conserved Domains (1) summary
    pfam00135
    Location:37 → 508
    COesterase; Carboxylesterase family

  2. XM_006530653.4 → XP_006530716.1  carboxylesterase 3B isoform X1

    Conserved Domains (1) summary
    pfam00135
    Location:37 → 520
    COesterase; Carboxylesterase family

  3. XM_006530655.4 → XP_006530718.1  carboxylesterase 3B isoform X4

    Conserved Domains (1) summary
    pfam00135
    Location:37 → 436
    COesterase; Carboxylesterase family

  4. XM_006530656.4 → XP_006530719.1  carboxylesterase 3B isoform X5

    Conserved Domains (1) summary
    pfam00135
    Location:37 → 435
    COesterase; Carboxylesterase family

  5. XM_006530657.4 → XP_006530720.1  carboxylesterase 3B isoform X6

    Conserved Domains (1) summary
    pfam00135
    Location:37 → 375
    COesterase; Carboxylesterase family

  6. XM_006530658.4 → XP_006530721.1  carboxylesterase 3B isoform X7

    Conserved Domains (1) summary
    cl21494
    Location:44 → 348
    Abhydrolase; alpha/beta hydrolases

  7. XM_017312561.2 → XP_017168050.1  carboxylesterase 3B isoform X3

    Conserved Domains (1) summary
    pfam00135
    Location:2 → 489
    COesterase; Carboxylesterase family

RNA

  1. XR_004934768.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCU1.2 GenPept UniProtKB/Swiss-Prot:Q8VCU1

Gene LinkOut

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