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Efna3 ephrin A3 [ Mus musculus (house mouse) ]

Gene ID: 13638, updated on 27-Nov-2024

Summary

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Official Symbol
Efna3provided by MGI
Official Full Name
ephrin A3provided by MGI
Primary source
MGI:MGI:106644
See related
Ensembl:ENSMUSG00000028039 AllianceGenome:MGI:106644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epl3; EFL-2; Ehk1-L; LERK-3
Summary
Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human EFNA3 (ephrin A3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 18.6), cortex adult (RPKM 12.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Efna3 in Genome Data Viewer
Location:
3 F1; 3 39.06 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89221200..89231359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89313899..89322939, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ephrin A1 Neighboring gene VISTA enhancer mm1415 Neighboring gene predicted gene, 33845 Neighboring gene predicted gene, 34014 Neighboring gene predicted gene 15998 Neighboring gene STARR-seq mESC enhancer starr_08230 Neighboring gene predicted gene, 34118 Neighboring gene ephrin A4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency. Fang Y, et al. Stem Cells, 2013 Feb. PMID 23165658, Free PMC Article
  2. Ephrin-A3 not only increases the density of hair follicles but also accelerates anagen development in neonatal mice. Yamada Y, et al. J Dermatol Sci, 2008 Dec. PMID 18640011
  3. Heparan sulfate regulates ephrin-A3/EphA receptor signaling. Irie F, et al. Proc Natl Acad Sci U S A, 2008 Aug 26. PMID 18715996, Free PMC Article
  4. Normal muscle fiber type distribution is recapitulated in aged ephrin-A3(-/-) mice that previously lacked most slow myofibers. Arpke RW, et al. Am J Physiol Cell Physiol, 2023 Mar 1. PMID 36717102, Free PMC Article
  5. Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders. Wurzman R, et al. Behav Brain Res, 2015 Feb 1. PMID 25281279, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptional regulation of the mouse EphA4, Ephrin-B2 and Ephrin-A3 genes by the circadian clock machinery.
    Title: Transcriptional regulation of the mouse EphA4, Ephrin-B2 and Ephrin-A3 genes by the circadian clock machinery.
  2. Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.
    Title: Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.
  3. Findings suggest a putative novel mechanism for desipramine to modulate long-term potentiation through the regulation of the ephrinA3/EphA4 signaling pathway
    Title: Desipramine targets astrocytes to attenuate synaptic plasticity via modulation of the ephrinA3/EphA4 signalling.
  4. The ephrin-A2/-A3 DKO mice have utility as a novel ASD model with an emphasis on sensory abnormalities and restricted, repetitive behavioral symptoms.
    Title: Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.
  5. Ephrin-A2 and -A3 are negative regulators of the proliferative and neurogenic potentials of Muller cells.
    Title: Ephrin-A2 and -A3 are negative regulators of the regenerative potential of Möller cells.
  6. Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency.
    Title: Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency.
  7. Downregulation of the EphA4 receptor via siRNA transfection reduced the repulsive effect of ephrin-A3, indicating that EphA4 mediates at least in part the repulsive effect of ephrin-A3.
    Title: Ephrins guide migrating cortical interneurons in the basal telencephalon.
  8. Data show that a number of Eph receptors and ephrins were expressed in hematopoietic stem cells.
    Title: Activation of ephrin A proteins influences hematopoietic stem cell adhesion and trafficking patterns.
  9. These results suggest that EphA4/ephrin-A3 signaling is a critical mechanism for astrocytes to regulate synaptic function and plasticity.
    Title: Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.
  10. Results suggest that the interaction between neuronal EphA4 and glial ephrin-A3 bidirectionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function.
    Title: Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC129300, MGC129301

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ephrin-A3
Names
EHK1 ligand
EPH-related receptor tyrosine kinase ligand 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377116.1 → NP_001364045.1  ephrin-A3 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC132327, AC171273
    UniProtKB/TrEMBL
    A0A0G2JGE9
    Related
    ENSMUSP00000143539.2, ENSMUST00000200436.2
    Conserved Domains (1) summary
    cd10425
    Location:31 → 158
    Ephrin-A_Ectodomain; Ectodomain of Ephrin A

  2. NM_001377117.1 → NP_001364046.1  ephrin-A3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AC132327, AC171273
    Conserved Domains (1) summary
    cl19115
    Location:1 → 77
    Cupredoxin; Cupredoxin superfamily

  3. NM_001377118.1 → NP_001364047.1  ephrin-A3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
    Source sequence(s)
    AC132327, AC171273
    Conserved Domains (1) summary
    cl19115
    Location:1 → 77
    Cupredoxin; Cupredoxin superfamily

  4. NM_001377119.1 → NP_001364048.1  ephrin-A3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AC132327, AC171273
    Conserved Domains (1) summary
    cl19115
    Location:1 → 77
    Cupredoxin; Cupredoxin superfamily

  5. NM_001377120.1 → NP_001364049.1  ephrin-A3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform d.
    Source sequence(s)
    AC132327, AC171273
    Conserved Domains (1) summary
    cl19115
    Location:1 → 77
    Cupredoxin; Cupredoxin superfamily

  6. NM_001377121.1 → NP_001364050.1  ephrin-A3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform d.
    Source sequence(s)
    AC132327, AC171273
    Conserved Domains (1) summary
    cl19115
    Location:1 → 77
    Cupredoxin; Cupredoxin superfamily

  7. NM_010108.2 → NP_034238.1  ephrin-A3 isoform a precursor

    See identical proteins and their annotated locations for NP_034238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC132327, AC171273
    Consensus CDS
    CCDS38488.1
    UniProtKB/Swiss-Prot
    O08545, O55217, Q08AV0
    Related
    ENSMUSP00000029673.6, ENSMUST00000029673.10
    Conserved Domains (1) summary
    cd10425
    Location:31 → 158
    Ephrin-A_Ectodomain; Ectodomain of Ephrin A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89221200..89231359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162885.1 → XP_036018778.1  ephrin-A3 isoform X1

    Conserved Domains (1) summary
    cl19115
    Location:1 → 77
    Cupredoxin; Cupredoxin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08545.4 GenPept UniProtKB/Swiss-Prot:O08545

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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