U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prl8a2 prolactin family 8, subfamily a, member 2 [ Mus musculus (house mouse) ]

Gene ID: 13529, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Prl8a2provided by MGI
Official Full Name
prolactin family 8, subfamily a, member 2provided by MGI
Primary source
MGI:MGI:894281
See related
Ensembl:ENSMUSG00000018259 AllianceGenome:MGI:894281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DPRP; Dtprp; Ghd11; mdPRP; D/tPRP
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Acts upstream of or within maternal process involved in female pregnancy and response to hypoxia. Predicted to be active in extracellular space. Is expressed in branchial arch; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward placenta adult (RPKM 101.9) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Prl8a2 in Genome Data Viewer
Location:
13 A3.1; 13 12.41 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27529656..27538199)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27345673..27354216)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 3, subfamily a, member 1 Neighboring gene craniofacial development protein 1 pseudogene Neighboring gene prolactin family 6, subfamily a, member 1 Neighboring gene STARR-seq mESC enhancer starr_34015 Neighboring gene prolactin family 2, subfamily b, member 1 Neighboring gene predicted gene, 40836 Neighboring gene prolactin family 8, subfamily a, member 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Histamine promotes mouse decidualization through stimulating epithelial amphiregulin release. Liu CK, et al. FEBS J, 2024 Sep. PMID 38973142
  2. Identification of target genes for a prolactin family paralog in mouse decidua. Alam SM, et al. Reproduction, 2015 Jun. PMID 25926690, Free PMC Article
  3. A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor. Alam SM, et al. Development, 2007 Jan. PMID 17166917
  4. Modulation of steroidogenic enzymes in murine lymphoid organs after immune activation. Mukhopadhyay R, et al. Immunol Invest, 2009. PMID 19172483
  5. Uterine Prx2 restrains decidual differentiation through inhibiting lipolysis in mice. Jiang Y, et al. Cell Tissue Res, 2016 Aug. PMID 26987819

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2.
    Title: Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2.
  2. The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2
    Title: Genome-Wide Association Mapping for Female Infertility in Inbred Mice.
  3. present in the lymphoid organs after immunization with soluble antigen
    Title: Modulation of steroidogenic enzymes in murine lymphoid organs after immune activation.
  4. 17 beta-estradiol and progesterone induced expression of mRNA for the decidual/trophoblastic PRL-related protein (d/tPRP) in cultured mouse endometrial stromal cells
    Title: Messenger ribonucleic acid for the mouse decidual prolactin is present and induced during in vitro decidualization of endometrial stromal cells.
  5. DPRP deficiency interfered with pregnancy-dependent adaptations to hypoxia resulting in pregnancy failure.
    Title: A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within maternal process involved in female pregnancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
prolactin family 8, subfamily a, member 2
Names
decidual/trophoblast prolactin-related protein
growth hormone d11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289919.1 → NP_001276848.1  prolactin family 8, subfamily a, member 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001276848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK131668, D19302
    Consensus CDS
    CCDS70440.1
    UniProtKB/TrEMBL
    O35258
    Related
    ENSMUSP00000105992.2, ENSMUST00000110363.9
    Conserved Domains (1) summary
    cd10288
    Location:29 → 239
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  2. NM_010088.2 → NP_034218.1  prolactin family 8, subfamily a, member 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF011385, AK131668, D19302
    Consensus CDS
    CCDS26396.1
    UniProtKB/TrEMBL
    O54832
    Related
    ENSMUSP00000018403.7, ENSMUST00000018403.8
    Conserved Domains (1) summary
    cd10288
    Location:30 → 240
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    27529656..27538199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools