ADORA2A adenosine A2a receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADORA2Aprovided by HGNC
Official Full Name: adenosine A2a receptorprovided by HGNC
Primary source: HGNC:HGNC:263
See related: Ensembl:ENSG00000128271 MIM:102776; AllianceGenome:HGNC:263
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: A2aR; RDC8; ADORA2
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Expression: Broad expression in bone marrow (RPKM 12.9), lymph node (RPKM 8.9) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q11.23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (24423597..24442357)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (24885210..24903991)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (24819565..24838325)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The adenosine A2A receptor in human sperm: its role in sperm motility and association with in vitro fertilization outcomes.
Title: The adenosine A2A receptor in human sperm: its role in sperm motility and association with in vitro fertilization outcomes.
Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer.
Title: Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer.
Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.
Title: Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.
Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.
Title: Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.
A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis.
Title: A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis.
CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4.
Title: CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4.
ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers.
Title: ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers.
ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma.
Title: ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma.
A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A1 adenosine receptor availability in the human brain.
Title: A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A(1) adenosine receptor availability in the human brain.
Adenosine A2A receptor availability in cerebral gray and white matter of patients with Parkinson's disease.
Title: Adenosine A(2A) receptor availability in cerebral gray and white matter of patients with Parkinson's disease.

Submit: New GeneRIF Correction See all GeneRIFs (330)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Activation of adenosine A2a receptor with CGS 21680 inhibits Tat-induced increases of intracellular calcium and this inhibition is dependent on protein phosphatase activity in monocytes	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-18996 (e-PCR)
- UniSTS:40515

G27964 (e-PCR)
- UniSTS:40778

ADORA2A (e-PCR)
- UniSTS:480136

D22S1263 (e-PCR)
- UniSTS:52178

Readthrough SPECC1L-ADORA2A

Readthrough gene: SPECC1L-ADORA2A, Included gene: SPECC1L

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled adenosine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-actinin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	EXP Inferred from Experiment more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables type 5 metabotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in astrocyte activation	IEA Inferred from Electronic Annotation more info
involved_in blood circulation	TAS Traceable Author Statement more info	PubMed
involved_in blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular defense response	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in eating behavior	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in inhibitory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of alpha-beta T cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of acetylcholine secretion, neurotransmission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of circadian sleep/wake cycle, sleep	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of urine volume	IEA Inferred from Electronic Annotation more info
involved_in prepulse inhibition	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of norepinephrine secretion	IEA Inferred from Electronic Annotation more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
involved_in response to caffeine	IEA Inferred from Electronic Annotation more info
involved_in response to purine-containing compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception	TAS Traceable Author Statement more info	PubMed
involved_in synaptic transmission, cholinergic	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in asymmetric synapse	IEA Inferred from Electronic Annotation more info
located_in axolemma	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenosine receptor A2a

Names: adenosine receptor subtype A2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052804.1 RefSeqGene

Range

9003..23761

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000675.6 → NP_000666.2 adenosine receptor A2a

See identical proteins and their annotated locations for NP_000666.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AK123058, BC013780, CA307692, DA942067

Consensus CDS

CCDS13826.1

UniProtKB/Swiss-Prot

B2R7E0, P29274

UniProtKB/TrEMBL

A8K1F6, B3KVQ4, X5DNB4

Related

ENSP00000336630.6, ENST00000337539.12

Conserved Domains (1) summary

cd15068
Location:7 → 299

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001278497.2 → NP_001265426.1 adenosine receptor A2a

See identical proteins and their annotated locations for NP_001265426.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants, 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AK289871, BG686029, CA307692, CN408252, HY249059

Consensus CDS

CCDS13826.1

UniProtKB/Swiss-Prot

B2R7E0, P29274

UniProtKB/TrEMBL

A8K1F6, B3KVQ4, X5DNB4

Related

ENSP00000480012.1, ENST00000610595.4

Conserved Domains (1) summary

cd15068
Location:7 → 299

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001278498.2 → NP_001265427.1 adenosine receptor A2a

See identical proteins and their annotated locations for NP_001265427.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

BG686029, CA307692, CR456367, DA270141, HY249059

Consensus CDS

CCDS13826.1

UniProtKB/Swiss-Prot

B2R7E0, P29274

UniProtKB/TrEMBL

A8K1F6, B3KVQ4, X5DNB4

Related

ENSP00000481552.1, ENST00000618076.3

Conserved Domains (1) summary

cd15068
Location:7 → 299

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001278499.2 → NP_001265428.1 adenosine receptor A2a

See identical proteins and their annotated locations for NP_001265428.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

BG686029, CA307692, CR456367, DA942067, HY249059

Consensus CDS

CCDS13826.1

UniProtKB/Swiss-Prot

B2R7E0, P29274

UniProtKB/TrEMBL

A8K1F6, B3KVQ4, X5DNB4

Conserved Domains (1) summary

cd15068
Location:7 → 299

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001278500.2 → NP_001265429.1 adenosine receptor A2a

See identical proteins and their annotated locations for NP_001265429.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

BG686029, CA307692, CR456367, DA781734, HY249059

Consensus CDS

CCDS13826.1

UniProtKB/Swiss-Prot

B2R7E0, P29274

UniProtKB/TrEMBL

A8K1F6, B3KVQ4, X5DNB4

Related

ENSP00000483102.1, ENST00000611543.4

Conserved Domains (1) summary

cd15068
Location:7 → 299

7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

NR_103543.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

BG686029, CA307692, DA687739, DA942067, HY102778, HY249059
NR_103544.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

BG686029, CA307692, DA687739, DA942067, DA983859, HY249059