U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dr1 down-regulator of transcription 1 [ Mus musculus (house mouse) ]

Gene ID: 13486, updated on 27-Nov-2024

Summary

Official Symbol
Dr1provided by MGI
Official Full Name
down-regulator of transcription 1provided by MGI
Primary source
MGI:MGI:1100515
See related
Ensembl:ENSMUSG00000029265 AllianceGenome:MGI:1100515
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NC2; Dr1l; NC2beta; 1700121L09Rik
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity and TBP-class protein binding activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Located in nucleus. Part of ATAC complex. Is expressed in central nervous system; early conceptus; genitourinary system; limb mesenchyme; and neural retina. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 18.6), adrenal adult (RPKM 14.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dr1 in Genome Data Viewer
Location:
5 F; 5 52.82 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108416763..108428387)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108268897..108280521)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 18 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 8190 Neighboring gene STARR-seq mESC enhancer starr_13907 Neighboring gene predicted gene, 54303 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class G Neighboring gene RIKEN cDNA 9330198I05 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
part_of negative cofactor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of negative cofactor 2 complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein Dr1
Names
NC2-beta
TATA-binding protein-associated phosphoprotein
negative cofactor 2-beta

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026106.4NP_080382.2  protein Dr1

    See identical proteins and their annotated locations for NP_080382.2

    Status: PROVISIONAL

    Source sequence(s)
    AC124107
    Consensus CDS
    CCDS19509.1
    UniProtKB/Swiss-Prot
    Q3UT14, Q91WV0
    Related
    ENSMUSP00000031190.5, ENSMUST00000031190.5
    Conserved Domains (1) summary
    cl23735
    Location:7130
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108416763..108428387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)