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SMIM43 small integral membrane protein 43 [ Homo sapiens (human) ]

Gene ID: 132332, updated on 27-Nov-2024

Summary

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Official Symbol
SMIM43provided by HGNC
Official Full Name
small integral membrane protein 43provided by HGNC
Primary source
HGNC:HGNC:55077
See related
Ensembl:ENSG00000164112 AllianceGenome:HGNC:55077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEMEP; TMEM155
Summary
Enables transmembrane transporter binding activity. Predicted to be involved in mesendoderm development. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 10.6), placenta (RPKM 2.0) and 1 other tissue See more
Orthologs
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Genomic context

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See SMIM43 in Genome Data Viewer
Location:
4q27
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (121758930..121765433, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (125062956..125069460, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122680085..122686588, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377402 Neighboring gene annexin A5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:122611545-122612744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15659 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:122633152-122634351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15660 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:122669697-122670300 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:122670301-122670904 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_72694 Neighboring gene uncharacterized LOC100192379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21868 Neighboring gene Sharpr-MPRA regulatory region 4891 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:122721667-122722470 Neighboring gene exosome component 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21871 Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21872

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells. Fu H, et al. Nat Commun, 2022 Jul 9. PMID 35810171, Free PMC Article
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30834

General protein information

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Preferred Names
small integral membrane protein 43
Names
Nodal Enhanced MEsendoderm Peptide
protein TMEM155
transmembrane protein 155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384332.1 → NP_001371261.1  small integral membrane protein 43

    Status: VALIDATED

    Source sequence(s)
    AC079341
    Consensus CDS
    CCDS93616.1
    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2
    Related
    ENSP00000495721.1, ENST00000643802.2

  2. NM_001384333.1 → NP_001371262.1  small integral membrane protein 43

    Status: VALIDATED

    Source sequence(s)
    AC079341
    Consensus CDS
    CCDS93616.1
    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2

  3. NM_001384334.1 → NP_001371263.1  small integral membrane protein 43

    Status: VALIDATED

    Source sequence(s)
    AC079341
    Consensus CDS
    CCDS93616.1
    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2
    Related
    ENST00000461198.5

RNA

  1. NR_169194.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079341
    Related
    ENST00000394396.5

  2. NR_169195.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079341

  3. NR_169196.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079341

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    121758930..121765433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    125062956..125069460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348898.1 → XP_054204873.1  small integral membrane protein 43 isoform X1

    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2

  2. XM_054348897.1 → XP_054204872.1  small integral membrane protein 43 isoform X1

    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001317837.2: Suppressed sequence

    Description
    NM_001317837.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  2. NM_001317838.2: Suppressed sequence

    Description
    NM_001317838.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  3. NM_001317839.2: Suppressed sequence

    Description
    NM_001317839.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  4. NM_001317841.2: Suppressed sequence

    Description
    NM_001317841.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  5. NM_001317842.2: Suppressed sequence

    Description
    NM_001317842.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  6. NM_001369019.1: Suppressed sequence

    Description
    NM_001369019.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  7. NM_152399.4: Suppressed sequence

    Description
    NM_152399.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
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