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M176.9 Tyrosine-protein kinase [ Caenorhabditis elegans ]

Gene ID: 13186458, updated on 4-Jan-2025

Summary

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Official Symbol
M176.9
Official Full Name
Tyrosine-protein kinase
Primary source
WormBase:WBGene00014813
Locus tag
CELE_M176.9
See related
AllianceGenome:WB:WBGene00014813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See M176.9 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (9409301..9411597, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene ncRNA Neighboring gene Glutathione synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase
NP_001305207.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9409301..9411597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318278.3 → NP_001305207.1  Tyrosine-protein kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S4FT70
    Conserved Domains (3) summary
    smart00219
    Location:239 → 484
    TyrKc; Tyrosine kinase, catalytic domain
    cd10361
    Location:116 → 212
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd00192
    Location:243 → 493
    PTKc; Catalytic domain of Protein Tyrosine Kinases

RNA

  1. NR_145829.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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