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Y106G6D.5 Helicase ATP-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 13181740, updated on 9-Dec-2024

Summary

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Official Symbol
Y106G6D.5
Official Full Name
Helicase ATP-binding domain-containing protein
Primary source
WormBase:WBGene00014965
Locus tag
CELE_Y106G6D.5
See related
AllianceGenome:WB:WBGene00014965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be active in nuclear body. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and autosomal recessive distal hereditary motor neuronopathy 1. Orthologous to human IGHMBP2 (immunoglobulin mu DNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y106G6D.5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (10119187..10122171, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Myb-like protein X Neighboring gene Protein kinase domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription termination site sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in termination of RNA polymerase II transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Helicase ATP-binding domain-containing protein
NP_001300390.1
  • Confirmed by transcript evidence
NP_001370940.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10119187..10122171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313461.3 → NP_001300390.1  Helicase ATP-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K2WNK1
    Conserved Domains (3) summary
    TIGR00376
    Location:55 → 653
    TIGR00376; DNA helicase, putative
    pfam13087
    Location:435 → 632
    AAA_12; AAA domain
    pfam13245
    Location:228 → 294
    AAA_19; Part of AAA domain

  2. NM_001383712.1 → NP_001370940.1  Helicase ATP-binding domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K2WN06
    Conserved Domains (2) summary
    COG1112
    Location:144 → 563
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13087
    Location:344 → 541
    AAA_12; AAA domain

RNA

  1. NR_132563.1 RNA Sequence

    Status: REVIEWED

  2. NR_132564.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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