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Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 [ Mus musculus (house mouse) ]

Gene ID: 13089, updated on 27-Nov-2024

Summary

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Official Symbol
Cyp2b13provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily b, polypeptide 13provided by MGI
Primary source
MGI:MGI:88599
See related
Ensembl:ENSMUSG00000040583 AllianceGenome:MGI:88599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including epoxygenase P450 pathway; steroid metabolic process; and xenobiotic catabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver adult (RPKM 50.7) See more
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Genomic context

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See Cyp2b13 in Genome Data Viewer
Location:
7 A3; 7 14.11 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25760813..25795622)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26061388..26096197)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 27, pseudogene Neighboring gene predicted gene, 51474 Neighboring gene ring finger protein 170, pseudogene Neighboring gene protein LTV1 homolog Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 26, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a cDNA clone for mouse phenobarbital-inducible cytochrome P-450b. Stupans I, et al. DNA, 1984. PMID 6547088
  2. Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution. Lakso M, et al. Eur J Biochem, 1991 Jan 30. PMID 1997326
  3. Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function. Damiri B, et al. Toxicol Sci, 2012 Feb. PMID 22083726, Free PMC Article
  4. Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver. Lundgren M, et al. Toxicology, 2007 Dec 5. PMID 17964055
  5. Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster. Wang H, et al. Environ Health Perspect, 2003 Nov. PMID 14630516, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report lentiviral-mediated RNAi knockdown of multiple mouse Cyp2b enzymes.
    Title: Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anandamide 11,12 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables anandamide 14,15 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables anandamide 8,9 epoxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables estrogen 2-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables testosterone 16-alpha-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 16-beta-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ketone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450, family 2, subfamily b, polypeptide 13
Names
cytochrome P450, 2b13, phenobarbitol inducible, type c
phenobarbital inducible, type c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007813.2 → NP_031839.2  cytochrome P450, family 2, subfamily b, polypeptide 13 precursor

    See identical proteins and their annotated locations for NP_031839.2

    Status: VALIDATED

    Source sequence(s)
    AC167357, AC171401, BC145895
    Consensus CDS
    CCDS21000.2
    UniProtKB/TrEMBL
    A6H6J2, E9Q713, Q64460
    Related
    ENSMUSP00000005669.8, ENSMUST00000005669.9
    Conserved Domains (1) summary
    pfam00067
    Location:42 → 488
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25760813..25795622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539508.4 → XP_006539571.1  cytochrome P450, family 2, subfamily b, polypeptide 13 isoform X1

    See identical proteins and their annotated locations for XP_006539571.1

    UniProtKB/TrEMBL
    Q64460
    Conserved Domains (1) summary
    pfam00067
    Location:82 → 514
    p450; Cytochrome P450

  2. XM_006539509.4 → XP_006539572.1  cytochrome P450, family 2, subfamily b, polypeptide 13 isoform X1

    See identical proteins and their annotated locations for XP_006539572.1

    UniProtKB/TrEMBL
    Q64460
    Conserved Domains (1) summary
    pfam00067
    Location:82 → 514
    p450; Cytochrome P450

  3. XM_006539510.4 → XP_006539573.1  cytochrome P450, family 2, subfamily b, polypeptide 13 isoform X2

    Conserved Domains (1) summary
    pfam00067
    Location:82 → 455
    p450; Cytochrome P450

  4. XM_006539511.2 → XP_006539574.1  cytochrome P450, family 2, subfamily b, polypeptide 13 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:2 → 381
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version

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