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LOC130061359 ATAC-STARR-seq lymphoblastoid silent region 8801 [ Homo sapiens (human) ]

Gene ID: 130061359, updated on 12-Sep-2024

Summary

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Gene symbol
LOC130061359
Gene description
ATAC-STARR-seq lymphoblastoid silent region 8801
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC130061359 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (61412698..61412757)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (62281543..62281602)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (59490059..59490118)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:59474489-59475040 Neighboring gene TBX2 promoter region Neighboring gene TBX2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:59482769-59483666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59487827-59488409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59494097-59494644 Neighboring gene long intergenic non-protein coding RNA 2875 Neighboring gene T-box transcription factor 2 Neighboring gene Sharpr-MPRA regulatory region 1503 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:59504513-59505712 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:59521182-59521392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59529753-59530594 Neighboring gene uncharacterized LOC124904042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:59531395-59532276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:59532277-59533157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59539816-59540478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59541142-59541803 Neighboring gene Sharpr-MPRA regulatory region 11492 Neighboring gene T-box transcription factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59553878-59554580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59554581-59555281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59563448-59564310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59564311-59565173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:59591549-59592049 Neighboring gene nascent polypeptide associated complex subunit alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_196539.1 

    Range
    101..160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    61412698..61412757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    62281543..62281602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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