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Crygf crystallin, gamma F [ Mus musculus (house mouse) ]

Gene ID: 12969, updated on 27-Nov-2024

Summary

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Official Symbol
Crygfprovided by MGI
Official Full Name
crystallin, gamma Fprovided by MGI
Primary source
MGI:MGI:88526
See related
Ensembl:ENSMUSG00000025945 AllianceGenome:MGI:88526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Len-2; Cryg-2; DGcry-2; 3110001K11Rik
Summary
Predicted to be a structural constituent of eye lens. Acts upstream of or within eye development. Is expressed in embryo; eye; head; lens; and retina. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Crygf in Genome Data Viewer
Location:
1 C3; 1 33.31 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65965681..65967470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65926522..65928311)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57567 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 16B pseudogene Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01181 Neighboring gene STARR-seq mESC enhancer starr_01182 Neighboring gene cell growth-regulating nucleolar protein Neighboring gene predicted gene 8812

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental regulation and cell type-specific expression of the murine gamma F-crystallin gene is mediated through a lens-specific element containing the gamma F-1 binding site. Goring DR, et al. Dev Dyn, 1993 Feb. PMID 8364223
  2. Functional interactions between retinoic acid receptor-related orphan nuclear receptor (ROR alpha) and the retinoic acid receptors in the regulation of the gamma F-crystallin promoter. Tini M, et al. J Biol Chem, 1995 Aug 25. PMID 7650034
  3. Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity. Graw J, et al. Invest Ophthalmol Vis Sci, 2002 Sep. PMID 12202521
  4. Novel zinc finger proteins that interact with the mouse gamma F-crystallin promoter and are expressed in the sclerotome during early somitogenesis. Liu Q, et al. Dev Biol, 1994 Sep. PMID 8088434
  5. Murine gamma E-crystallin is distinct from murine gamma 2-crystallin. Graw J, et al. Gene, 1991 Aug 15. PMID 1916296

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crygf(Rop) is the first mutation affecting the Crygf gene.
    Title: Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (other) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of eye lens IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gamma-crystallin F
Names
gamma-F-crystallin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360779.1 → NP_001347708.1  gamma-crystallin F isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK013953, CA326162, CA452192
    Consensus CDS
    CCDS87841.1
    UniProtKB/TrEMBL
    E9Q3I1
    Related
    ENSMUSP00000109661.3, ENSMUST00000114027.3
    Conserved Domains (1) summary
    smart00247
    Location:3 → 82
    XTALbg; Beta/gamma crystallins

  2. NM_027010.3 → NP_081286.1  gamma-crystallin F isoform 1

    See identical proteins and their annotated locations for NP_081286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK013953, CA326162
    Consensus CDS
    CCDS15018.1
    UniProtKB/Swiss-Prot
    Q9CXV3
    UniProtKB/TrEMBL
    A2RTH4
    Related
    ENSMUSP00000027082.5, ENSMUST00000027082.11
    Conserved Domains (2) summary
    smart00247
    Location:3 → 82
    XTALbg; Beta/gamma crystallins
    pfam00030
    Location:89 → 170
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    65965681..65967470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXV3.3 GenPept UniProtKB/Swiss-Prot:Q9CXV3

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