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LOC129664154 ReSE screen-validated silencer GRCh37_chr17:75319666-75319839 [ Homo sapiens (human) ]

Gene ID: 129664154, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129664154
Gene description
ReSE screen-validated silencer GRCh37_chr17:75319666-75319839
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129664154 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (77323584..77323757)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (78216826..78216999)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (75319666..75319839)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:75250208-75251407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75253655-75254312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75254313-75254968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75262063-75262564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75262565-75263064 Neighboring gene lung adenocarcinoma-associated transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75275663-75276310 Neighboring gene SEPTIN9 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr17:75277912-75278075 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:75281897-75283096 Neighboring gene septin 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75299804-75300691 Neighboring gene HNF4 motif-containing MPRA enhancer 212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75304718-75305262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75306143-75306644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75310435-75311270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75312943-75313778 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:75316721-75316933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75322007-75322925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75325959-75326536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75326537-75327112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75352605-75353106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75359740-75360398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75360399-75361055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75371719-75372408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75373534-75374144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75378629-75379166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75379167-75379704 Neighboring gene uncharacterized LOC124904062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75385497-75386227 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75387689-75388418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75388419-75389149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75389150-75389879 Neighboring gene microRNA 4316

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_161160.1 

    Range
    101..274
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    77323584..77323757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    78216826..78216999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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