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LOC129663658 ReSE screen-validated silencer GRCh37_chr15:75329616-75329854 [ Homo sapiens (human) ]

Gene ID: 129663658, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129663658
Gene description
ReSE screen-validated silencer GRCh37_chr15:75329616-75329854
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129663658 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75037275..75037513)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72907265..72907503)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75329616..75329854)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75246929-75247862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75247863-75248796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75248797-75249730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75250725-75251281 Neighboring gene ribonuclease P and MRP subunit p25 Neighboring gene secretory carrier membrane protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75323765-75324265 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75326220-75326413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75328766-75329266 Neighboring gene phosphopantothenoylcysteine decarboxylase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9821 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:75335422-75336621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6663 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75343839-75344340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75344341-75344840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9830 Neighboring gene uncharacterized LOC124903529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9834 Neighboring gene stromal cell derived factor 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160664.1 

    Range
    101..339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    75037275..75037513
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    72907265..72907503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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