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LOC129662898 ReSE screen-validated silencer GRCh37_chr11:35173058-35173288 [ Homo sapiens (human) ]

Gene ID: 129662898, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129662898
Gene description
ReSE screen-validated silencer GRCh37_chr11:35173058-35173288
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129662898 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (35151511..35151741)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (35289575..35289805)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (35173058..35173288)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4614 Neighboring gene uncharacterized LOC105376627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4616 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:35137568-35138767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35159883-35160447 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35161615-35162115 Neighboring gene CD44 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4618 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:35173309-35174101 Neighboring gene CD44 molecule (IN blood group) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4619 Neighboring gene small nucleolar RNA, C/D box 164 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35194606-35195107 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35227049-35227813 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:35235787-35236986 Neighboring gene CD44 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_159905.1 

    Range
    101..331
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    35151511..35151741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    35289575..35289805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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