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LYG1 lysozyme g1 [ Homo sapiens (human) ]

Gene ID: 129530, updated on 27-Nov-2024

Summary

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Official Symbol
LYG1provided by HGNC
Official Full Name
lysozyme g1provided by HGNC
Primary source
HGNC:HGNC:27014
See related
Ensembl:ENSG00000144214 AllianceGenome:HGNC:27014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYGA1; SALW1939
Summary
Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney (RPKM 2.5), testis (RPKM 0.7) and 11 other tissues See more
Orthologs
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Genomic context

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See LYG1 in Genome Data Viewer
Location:
2q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (99284238..99304775, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99742858..99763389, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99900701..99921238, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99797856-99798028 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme g2 Neighboring gene uncharacterized LOC107985923 Neighboring gene thioredoxin domain containing 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99952564-99953104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99953733-99954234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99954235-99954734 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene REV1 DNA directed polymerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular evolution of vertebrate goose-type lysozyme genes. Irwin DM, et al. J Mol Evol, 2003 Feb. PMID 12574869
  2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Nat Genet, 2011 Sep 18. PMID 21926972, Free PMC Article
  3. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysozyme g-like protein 1
Names
lysozyme G-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371380.1 → NP_001358309.1  lysozyme g-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC079447
    Consensus CDS
    CCDS2043.1
    UniProtKB/Swiss-Prot
    Q53RV9, Q8N1E2
    Related
    ENSP00000386923.1, ENST00000409448.1
    Conserved Domains (1) summary
    cd16888
    Location:38 → 194
    lyz_G-like_1; lysozyme G-like protein 1

  2. NM_174898.3 → NP_777558.1  lysozyme g-like protein 1 precursor

    See identical proteins and their annotated locations for NP_777558.1

    Status: VALIDATED

    Source sequence(s)
    AC079447, BC029126, BG194505
    Consensus CDS
    CCDS2043.1
    UniProtKB/Swiss-Prot
    Q53RV9, Q8N1E2
    Related
    ENSP00000311320.4, ENST00000308528.9
    Conserved Domains (1) summary
    cd16888
    Location:38 → 194
    lyz_G-like_1; lysozyme G-like protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    99284238..99304775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443274.1 → XP_047299230.1  lysozyme g-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q53RV9, Q8N1E2

  2. XM_047443275.1 → XP_047299231.1  lysozyme g-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q53RV9, Q8N1E2

  3. XM_011510580.2 → XP_011508882.1  lysozyme g-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011508882.1

    UniProtKB/Swiss-Prot
    Q53RV9, Q8N1E2
    Conserved Domains (1) summary
    cd16888
    Location:38 → 194
    lyz_G-like_1; lysozyme G-like protein 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    99742858..99763389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340478.1 → XP_054196453.1  lysozyme g-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q53RV9, Q8N1E2

  2. XM_054340477.1 → XP_054196452.1  lysozyme g-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q53RV9, Q8N1E2

  3. XM_054340479.1 → XP_054196454.1  lysozyme g-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q53RV9, Q8N1E2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N1E2.1 GenPept UniProtKB/Swiss-Prot:Q8N1E2

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