Cnr1 cannabinoid receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnr1provided by MGI
Official Full Name: cannabinoid receptor 1provided by MGI
Primary source: MGI:MGI:104615
See related: Ensembl:ENSMUSG00000044288 AllianceGenome:MGI:104615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CB1; CB-R; CB1A; CB1B; CB1R
Summary: Enables cannabinoid receptor activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within axonal fasciculation and glucose homeostasis. Located in growth cone. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 24.0), CNS E18 (RPKM 17.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 16.28 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (33923171..33948831)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (33923171..33948831)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigating the Role of Cannabinoid Type 1 Receptors in Vascular Function and Remodeling in a Hypercholesterolemic Mouse Model with Low-Density Lipoprotein-Cannabinoid Type 1 Receptor Double Knockout Animals.
Title: Investigating the Role of Cannabinoid Type 1 Receptors in Vascular Function and Remodeling in a Hypercholesterolemic Mouse Model with Low-Density Lipoprotein-Cannabinoid Type 1 Receptor Double Knockout Animals.
Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome.
Title: Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome.
Gut Microbiota-Mediated Alterations of Hippocampal CB1R Regulating the Diurnal Variation of Cognitive Impairment Induced by Hepatic Ischemia-Reperfusion Injury in Mice.
Title: Gut Microbiota-Mediated Alterations of Hippocampal CB1R Regulating the Diurnal Variation of Cognitive Impairment Induced by Hepatic Ischemia-Reperfusion Injury in Mice.
Cannabinoid receptor type 1 activation causes a water diuresis by inducing an acute central diabetes insipidus in mice.
Title: Cannabinoid receptor type 1 activation causes a water diuresis by inducing an acute central diabetes insipidus in mice.
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.
Title: The CB(1) receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.
A Sexually Dimorphic Role for Intestinal Cannabinoid Receptor Subtype-1 in the Behavioral Expression of Anxiety.
Title: A Sexually Dimorphic Role for Intestinal Cannabinoid Receptor Subtype-1 in the Behavioral Expression of Anxiety.
Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice.
Title: Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice.
Role of Type I Cannabinoid Receptor in Sensory Neurons in Psoriasiform Skin Inflammation and Pruritus.
Title: Role of Type I Cannabinoid Receptor in Sensory Neurons in Psoriasiform Skin Inflammation and Pruritus.
CB1 Receptor Silencing Attenuates Ketamine-Induced Hyperlocomotion Without Compromising Its Antidepressant-Like Effects.
Title: CB1 Receptor Silencing Attenuates Ketamine-Induced Hyperlocomotion Without Compromising Its Antidepressant-Like Effects.
The Expression and Functionality of CB1R-NMDAR Complexes Are Decreased in A Parkinson's Disease Model.
Title: The Expression and Functionality of CB(1)R-NMDAR Complexes Are Decreased in A Parkinson's Disease Model.

Submit: New GeneRIF Correction See all GeneRIFs (428)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (23) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cnr1 (e-PCR), detects polymorphism
- UniSTS:141363

PMC123076P1 (e-PCR)
- UniSTS:270436

PMC193595P1 (e-PCR)
- UniSTS:271751

PMC166293P1 (e-PCR)
- UniSTS:271579

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cannabinoid receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cannabinoid receptor activity	ISO Inferred from Sequence Orthology more info
enables cannabinoid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cannabinoid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cannabinoid signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IPI Inferred from Physical Interaction more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of action potential	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serotonin secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of penile erection	IEA Inferred from Electronic Annotation more info
involved_in regulation of penile erection	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in retrograde trans-synaptic signaling by endocannabinoid	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde trans-synaptic signaling by endocannabinoid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cannabinoid receptor 1

Names: brain-type cannabinoid receptor; cannabinoid receptor 1 (brain); striatal cannabinoid receptor type 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355020.2 → NP_001341949.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

BX005292

Consensus CDS

CCDS18025.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001355021.2 → NP_001341950.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

BX005292

Consensus CDS

CCDS18025.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001365881.1 → NP_001352810.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

BX005292

Consensus CDS

CCDS18025.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Related

ENSMUSP00000081787.3, ENSMUST00000084736.3

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_007726.5 → NP_031752.1 cannabinoid receptor 1

See identical proteins and their annotated locations for NP_031752.1

Status: VALIDATED

Source sequence(s)

BX005292

Consensus CDS

CCDS18025.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Related

ENSMUSP00000055797.7, ENSMUST00000057188.7

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

33923171..33948831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253149.1 → XP_030109009.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537594.4 → XP_006537657.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537657.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537595.4 → XP_006537658.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537658.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036163625.1 → XP_036019518.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537592.5 → XP_006537655.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537655.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036163626.1 → XP_036019519.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537591.4 → XP_006537654.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537654.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006537593.4 → XP_006537656.1 cannabinoid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006537656.1

UniProtKB/Swiss-Prot

P47746, Q5SF33

UniProtKB/TrEMBL

A0A385KNU8

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors