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mir-92a mir-92a stem loop [ Drosophila melanogaster (fruit fly) ]

Gene ID: 12798262, updated on 17-Dec-2024

Summary

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Official Symbol
mir-92aprovided by FlyBase
Official Full Name
mir-92a stem loopprovided by FlyBase
Primary source
FLYBASE:FBgn0262411
Locus tag
Dmel_CR42955
See related
miRBase:MI0000357; AllianceGenome:FB:FBgn0262411
Gene type
ncRNA
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CR33571; CR42955; dme-mir-92a; dme-miR-92a; Dmel\CR42955; mir-92; miR-92; MIR-92; miR-92a; miR-92A; mIR-92a
Old locus tag
Dmel_CR33571
Summary
Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including miRNA-mediated post-transcriptional gene silencing; positive regulation of circadian sleep/wake cycle, sleep; and regulation of olfactory learning. Is expressed in embryonic brain; larval ventral nerve cord; and mesothoracic leg. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mir-92a in Genome Data Viewer
Location:
96E6-96E6; 3-88 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25646506..25646600)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21472228..21472322)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nuclear protein localization 4 Neighboring gene uncharacterized protein Neighboring gene Succinic semialdehyde dehydrogenase Neighboring gene jing interacting gene regulatory 1 Neighboring gene long non-coding RNA:CR45917 Neighboring gene mir-92b stem loop Neighboring gene antisense RNA:CR46101 Neighboring gene tankyrase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila. Chen X, et al. Nat Commun, 2017 Mar 9. PMID 28276426, Free PMC Article
  2. Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster. Arif S, et al. Curr Biol, 2013 Mar 18. PMID 23453955, Free PMC Article
  3. From shavenbaby to the naked valley: trichome formation as a model for evolutionary developmental biology. Arif S, et al. Evol Dev, 2015 Jan-Feb. PMID 25627718
  4. Downregulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila. Yuva-Aydemir Y, et al. PLoS Genet, 2015 May. PMID 26000445, Free PMC Article
  5. miR-92a Suppresses Mushroom Body-Dependent Memory Consolidation in Drosophila. Guven-Ozkan T, et al. eNeuro, 2020 Jul/Aug. PMID 32737186, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-92a Suppresses Mushroom Body-Dependent Memory Consolidation in Drosophila.
    Title: miR-92a Suppresses Mushroom Body-Dependent Memory Consolidation in Drosophila.
  2. Data indicate that sirt2 is a functional mir-92a target and that mir-92a modulates pigment dispersing factor (PDF) neuronal excitability via suppressing SIRT2 levels in a rhythmic manner.
    Title: MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila.
  3. We show that miR-92a and miR-92b directly target jigr1 in vivo and that some phenotypes due to the absence of these miRNAs are partially rescued by reducing the level of jigr1.
    Title: Downregulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila.
  4. miR-92 family act like an allelic series to cause wing hair loss
    Title: Functional characterization of Drosophila microRNAs by a novel in vivo library.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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  • alternate names: miR-92a; mir-92
  • mir-92a-RA; Dmel\mir-92a-RA; CR42955-RA; Dmel\CR42955-RA
  • mir-92a-RB; Dmel\mir-92a-RB; CR42955-RB; Dmel\CR42955-RB
  • mir-92a-RM; Dmel\mir-92a-RM; CR42955-RM; Dmel\CR42955-RM

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cuticle pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuroblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25646506..25646600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_048486.1 RNA Sequence

    Status: REVIEWED

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials